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Tchem
USP30
Ubiquitin carboxyl-terminal hydrolase 30

Protein Summary
Description
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257548
  • ENSP00000257548
  • ENSG00000135093
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor binding site profile
0.73
cellular component
0.64
cell type or tissue
0.63
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.56   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 428
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (112)
POMK
Tbio
Family:  Kinase
Novelty:  0.09340344
p_int:  0.998840717
p_ni:  0.001159203
p_wrong:  8e-8
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.998472141
p_ni:  0.001527859
Data Source:  BioPlex
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.995983242
p_ni:  0.004016745
p_wrong:  1.3e-8
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.994396008
p_ni:  0.005603979
p_wrong:  1.3e-8
Data Source:  BioPlex
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.994209505
p_ni:  0.005790494
p_wrong:  1e-9
Score:  0.171
Data Source:  BioPlex,STRINGDB
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.981373381
p_ni:  0.018626426
p_wrong:  1.92e-7
Data Source:  BioPlex
EXT2
Tbio
Family:  Enzyme
Novelty:  0.00480574
p_int:  0.979750387
p_ni:  0.020249612
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
C1QB
Tbio
Novelty:  0.01476497
p_int:  0.976817374
p_ni:  0.023182626
Score:  0.21
Data Source:  BioPlex,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.964253508
p_ni:  0.035746492
Data Source:  BioPlex
PVR
Tbio
Novelty:  0.00215811
p_int:  0.947726712
p_ni:  0.052243916
p_wrong:  0.000029372
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Deubiquitination (R-HSA-5688426)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
95.3
platelet count
2
2
2
94.8
mitochondrial DNA measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
95.3
platelet count
2
94.8
mitochondrial DNA measurement
1
57.8
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 30
VGNC:13490
452215
Macaque
ubiquitin specific peptidase 30
706607
Mouse
MGI:2140991
100756
Rat
RGD:1307949
304579
Dog
ubiquitin specific peptidase 30
VGNC:52974
611662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 30
Macaque
ubiquitin specific peptidase 30
Mouse
Rat
Dog
ubiquitin specific peptidase 30
Publication Statistics
PubMed Score 33.56
PubMed score by year
PubTator Score 18.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title