You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
USP30
Ubiquitin carboxyl-terminal hydrolase 30

Protein Summary
Description
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257548
  • ENSP00000257548
  • ENSG00000135093
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor binding site profile
0.73
cellular component
0.64
cell type or tissue
0.63
transcription factor
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.27   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.27   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
74.5
platelet count
2
2
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
74.5
platelet count
2
74
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 30
VGNC:13490
452215
Macaque
ubiquitin specific peptidase 30
706607
Mouse
MGI:2140991
100756
Rat
RGD:1307949
304579
Dog
ubiquitin specific peptidase 30
VGNC:52974
611662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 30
Macaque
ubiquitin specific peptidase 30
Mouse
Rat
Dog
ubiquitin specific peptidase 30
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q70CQ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Protein-Protein Interactions (112)
1 – 10 of 112
POMK
Tbio
Family: Kinase
Novelty: 0.09340344
p_int: 0.998840717
p_ni: 0.001159203
p_wrong: 8e-8
Data Source: BioPlex
CLEC2B
Tbio
Novelty: 0.06581244
p_int: 0.998472141
p_ni: 0.001527859
Data Source: BioPlex
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.995983242
p_ni: 0.004016745
p_wrong: 1.3e-8
Data Source: BioPlex
GRPR
Tchem
Family: GPCR
Novelty: 0.00282511
p_int: 0.994396008
p_ni: 0.005603979
p_wrong: 1.3e-8
Data Source: BioPlex
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.994209505
p_ni: 0.005790494
p_wrong: 1e-9
Score: 0.171
Data Source: BioPlex,STRINGDB
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.981373381
p_ni: 0.018626426
p_wrong: 1.92e-7
Data Source: BioPlex
EXT2
Tbio
Family: Enzyme
Novelty: 0.00480574
p_int: 0.979750387
p_ni: 0.020249612
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
C1QB
Tbio
Novelty: 0.01476497
p_int: 0.976817374
p_ni: 0.023182626
Score: 0.21
Data Source: BioPlex,STRINGDB
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.964253508
p_ni: 0.035746492
Data Source: BioPlex
PVR
Tbio
Novelty: 0.00215811
p_int: 0.947726712
p_ni: 0.052243916
p_wrong: 0.000029372
Data Source: BioPlex
Publication Statistics
PubMed Score  29.27

PubMed score by year
PubTator Score  18.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer