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Tbio
USP49
Ubiquitin carboxyl-terminal hydrolase 49

Protein Summary
Description
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373006
  • ENSP00000362097
  • ENSG00000164663
  • ENST00000394253
  • ENSP00000377797
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
protein domain
0.73
transcription factor binding site profile
0.71
cell type or tissue
0.67
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
4
4
92.1
mean reticulocyte volume
1
2
2
66.5
reticulocyte count
1
1
1
31.3
neutrophil percentage of leukocytes
1
1
1
27
erythrocyte count
1
1
1
22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
92.1
mean reticulocyte volume
2
66.5
reticulocyte count
1
31.3
neutrophil percentage of leukocytes
1
27
erythrocyte count
1
22
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (74)
1 – 10 of 74
CETN2
Tbio
Novelty: 0.00641301
p_int: 0.97310915
p_ni: 0.02689085
Score: 0.468
Data Source: BioPlex,STRINGDB
CETN3
Tbio
Novelty: 0.00705513
p_int: 0.941441495
p_ni: 0.058558504
p_wrong: 1e-9
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.752968759
p_ni: 0.247031241
Data Source: BioPlex
HIST2H2BE
Tbio
Novelty: 0.00024381
Score: 0.959
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.941
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.935
Data Source: STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
Score: 0.93
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.924
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.924
Data Source: STRINGDB
HIST1H2BK
Tbio
Novelty: 0.12867647
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.78

PubMed score by year
PubTator Score  1.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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