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Tbio
ACAD11
Acyl-CoA dehydrogenase family member 11

Protein Summary
Description
Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264990
  • ENSP00000264990
  • ENSG00000240303

Symbol
  • ACAD-11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor perturbation
0.88
protein domain
0.85
cell type or tissue
0.82
molecular function
0.73


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.81   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.81   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
94.5
low density lipoprotein cholesterol measurement
5
5
6
90.1
alkaline phosphatase measurement
2
2
1
6.7
86.8
apolipoprotein B measurement
2
3
3
86.7
hemoglobin measurement
2
2
2
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
94.5
low density lipoprotein cholesterol measurement
6
90.1
alkaline phosphatase measurement
1
6.7
86.8
apolipoprotein B measurement
3
86.7
hemoglobin measurement
2
79.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 11
VGNC:11320
100615854
Mouse
MGI:2143169
102632
Rat
RGD:1306270
315973
Dog
acyl-CoA dehydrogenase family member 11
VGNC:37491
100856488
Horse
acyl-CoA dehydrogenase family member 11
VGNC:14964
100629864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 11
Mouse
Rat
Dog
acyl-CoA dehydrogenase family member 11
Horse
acyl-CoA dehydrogenase family member 11
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q709F0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (87)
1 – 10 of 87
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999991318
p_ni:  0.000008683
Data Source:  BioPlex
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999990047
p_ni:  0.000009953
Score:  0.539
Data Source:  BioPlex,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999962021
p_ni:  0.000037979
Data Source:  BioPlex
DCAF8L2
Tdark
Novelty:  6.73057868
p_int:  0.999957881
p_ni:  0.000042119
Data Source:  BioPlex
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.999956998
p_ni:  0.000043002
Data Source:  BioPlex
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.999934218
p_ni:  0.000065782
Data Source:  BioPlex
GTSE1
Tbio
Family:  Enzyme
Novelty:  0.0460569
p_int:  0.9998929
p_ni:  0.0001071
Data Source:  BioPlex
PDYN
Tbio
Novelty:  0.00039564
p_int:  0.999707951
p_ni:  0.000292049
Score:  0.167
Data Source:  BioPlex,STRINGDB
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.999697584
p_ni:  0.000302416
Data Source:  BioPlex
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.999245794
p_ni:  0.000754206
Data Source:  BioPlex
Publication Statistics
PubMed Score  2.81

PubMed score by year
PubTator Score  1.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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