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Tbio
CYP4V2
Cytochrome P450 4V2

Protein Summary
Description
Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye (PubMed:19661213, PubMed:22772592). Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12) (PubMed:19661213). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22-hydroxydocosahexaenoate (PubMed:22772592). Also produces some 21-hydroxydocosahexaenoate. Also converts eicosapentaenoate (EPA) to 20-hydroxyeicosapentaenoate (20-OH-EPA) (PubMed:22772592). This gene encodes a member of the cytochrome P450 hemethiolate protein superfamily which are involved in oxidizing various substrates in the metabolic pathway. It is implicated in the metabolism of fatty acid precursors into n-3 poly ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378802
  • ENSP00000368079
  • ENSG00000145476

Symbol
  • BCD
  • CYP4AH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.87
virus perturbation
0.72
kinase perturbation
0.71
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.1   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.1   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
7
7
1
1.2
99
blood metabolite measurement
2
3
3
95.6
partial thromboplastin time
1
3
3
92.2
serum metabolite measurement
2
2
3
89
factor XI measurement
1
1
1
88.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1.2
99
blood metabolite measurement
3
95.6
partial thromboplastin time
3
92.2
serum metabolite measurement
3
89
factor XI measurement
1
88.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily V member 2
VGNC:6417
744981
Macaque
cytochrome P450, family 4, subfamily V, polypeptide 2
696520
Mouse
MGI:2142763
102294
Rat
RGD:708530
266761
Dog
cytochrome P450 family 4 subfamily V member 2
VGNC:50369
102152484
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 4 subfamily V member 2
Macaque
cytochrome P450, family 4, subfamily V, polypeptide 2
Mouse
Rat
Dog
cytochrome P450 family 4 subfamily V member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZWL3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Endogenous sterols
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Endogenous sterols
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (29)
1 – 10 of 29
GATC
Tbio
Family:  Enzyme
Novelty:  0.62484697
p_int:  0.979963882
p_ni:  0.020004742
p_wrong:  0.000031375
Score:  0.19
Data Source:  BioPlex,STRINGDB
NEMF
Tbio
Novelty:  0.05052246
p_int:  0.902064655
p_ni:  0.09793502
p_wrong:  3.25e-7
Score:  0.269
Data Source:  BioPlex,STRINGDB
ABCB6
Tbio
Family:  Transporter
Novelty:  0.00552057
Score:  0.599
Data Source:  STRINGDB
POR
Tbio
Family:  Enzyme
Novelty:  0.00145147
Score:  0.594
Data Source:  STRINGDB
HSD17B11
Tbio
Family:  Enzyme
Novelty:  0.06825283
Score:  0.578
Data Source:  STRINGDB
ZNF770
Tdark
Family:  TF
Novelty:  0.79192428
Score:  0.567
Data Source:  STRINGDB
PDZD7
Tbio
Novelty:  0.09467006
Score:  0.562
Data Source:  STRINGDB
FAM149A
Tdark
Novelty:  0.58381103
Score:  0.538
Data Source:  STRINGDB
PCYT1A
Tchem
Family:  Enzyme
Novelty:  0.00621528
Score:  0.536
Data Source:  STRINGDB
DIEXF
Tbio
Novelty:  0.05892659
Score:  0.51
Data Source:  STRINGDB
Publication Statistics
PubMed Score  193.10

PubMed score by year
PubTator Score  1012.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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