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Tdark
TMPRSS11F
Transmembrane protease serine 11F

Protein Summary
Description
Probable serine protease.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356291
  • ENSP00000348639
  • ENSG00000198092

Symbol
  • HATL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
protein domain
0.85
cell line
0.58
microRNA
0.51
tissue
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
1
1
0
12.2
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
0
12.2
31.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 11F
VGNC:2056
100613841
Macaque
transmembrane protease serine 11F
710088
Mouse
MGI:2442348
243083
Rat
RGD:1560675
498345
Dog
transmembrane protease serine 11F
482174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 11F
Macaque
transmembrane protease serine 11F
Mouse
Rat
Dog
transmembrane protease serine 11F
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZWK6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (7)
1 – 7 of 7
SPRTN
Tbio
Novelty:  0.0388393
Score:  0.656
Data Source:  STRINGDB
ASGR1
Tbio
Novelty:  0.00209845
Score:  0.482
Data Source:  STRINGDB
CLEC10A
Tbio
Novelty:  0.00656565
Score:  0.482
Data Source:  STRINGDB
DNAH14
Tdark
Novelty:  0.28289652
Score:  0.448
Data Source:  STRINGDB
DNAJB14
Tbio
Novelty:  0.6283107
Score:  0.428
Data Source:  STRINGDB
ADAM32
Tdark
Family:  Enzyme
Novelty:  0.36071191
Score:  0.424
Data Source:  STRINGDB
TSPYL1
Tbio
Novelty:  0.06381144
Score:  0.4
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.92

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer