Tdark KCP Kielin/chordin-like protein

Protein Summary

Description

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Uniprot Accession IDs

• Q6ZWJ8
• A0A087WT73
• Q8NBE0

Gene Name

• KCP

Ensembl ID

• ENST00000613019
• ENSP00000477644
• ENSG00000135253

Symbol

• CRIM2
• KCP1
• KCP1
• CRIM2
• NET67

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.58
tissue sample	0.53
cell type or tissue	0.46
cell line	0.45
histone modification site profile	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.73   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 166.73   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0