Tbio KCTD8 BTB/POZ domain-containing protein KCTD8

Protein Summary

Description

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).

Uniprot Accession IDs

• Q6ZWB6
• A2RU39

Gene Name

• KCTD8

Ensembl ID

• ENST00000360029
• ENSP00000353129
• ENSG00000183783

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.63
histone modification site profile	0.62
transcription factor binding site profile	0.59
cell line	0.47
cell type or tissue	0.46

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd8

DTO Classes

Protein / Enzyme Modulator / Btb/poz Domain-containing Protein Kctd8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.18   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0