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Tdark
TOM1L2
TOM1-like protein 2

Protein Summary
Description
Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318094
  • ENSP00000312860
  • ENSG00000175662
  • ENST00000379504
  • ENSP00000368818
  • ENST00000395739
  • ENSP00000379088
  • ENST00000478943
  • ENSP00000463313
  • ENST00000535933
  • ENSP00000438621
  • ENST00000581396
  • ENSP00000464297
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
histone modification site profile
0.78
transcription factor
0.78
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
SZRD1
Tdark
Novelty:  0.81300551
p_int:  0.997565177
p_ni:  0.002422673
p_wrong:  0.000012151
Score:  0.485
Data Source:  BioPlex,STRINGDB
NDUFA6
Tclin
Family:  Enzyme
Novelty:  0.01236094
p_int:  0.99686957
p_ni:  0.00313043
Score:  0.622
Data Source:  BioPlex,STRINGDB
TOLLIP
Tbio
Novelty:  0.01032371
p_int:  0.988422665
p_ni:  0.011577335
Score:  0.708
Data Source:  BioPlex,STRINGDB
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.980503363
p_ni:  0.019496638
Score:  0.665
Data Source:  BioPlex,STRINGDB
ZFYVE16
Tbio
Novelty:  0.10765234
Score:  0.804
Data Source:  STRINGDB
SULT1A1
Tchem
Family:  Enzyme
Novelty:  0.00238409
Score:  0.799
Data Source:  STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.796
Data Source:  STRINGDB
S100A4
Tchem
Novelty:  0.00136919
Score:  0.78
Data Source:  STRINGDB
SRXN1
Tbio
Novelty:  0.00780861
Score:  0.774
Data Source:  STRINGDB
RCN1
Tbio
Novelty:  0.00857135
Score:  0.771
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
93.9
waist-hip ratio
2
7
7
89
BMI-adjusted waist-hip ratio
2
7
7
88
lymphocyte count
2
2
2
86.8
4
3
3
1.1
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
93.9
waist-hip ratio
7
89
BMI-adjusted waist-hip ratio
7
88
lymphocyte count
2
86.8
3
1.1
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
target of myb1 like 2 membrane trafficking protein
VGNC:9731
454481
Macaque
target of myb1 like 2 membrane trafficking protein
699471
Mouse
MGI:2443306
216810
Dog
target of myb1 like 2 membrane trafficking protein
VGNC:47709
489540
Horse
target of myb1 like 2 membrane trafficking protein
VGNC:24409
100052159
Species
Name
OMA
EggNOG
Inparanoid
Chimp
target of myb1 like 2 membrane trafficking protein
Macaque
target of myb1 like 2 membrane trafficking protein
Mouse
Dog
target of myb1 like 2 membrane trafficking protein
Horse
target of myb1 like 2 membrane trafficking protein
Publication Statistics
PubMed Score 4.29
PubMed score by year
PubTator Score 4.66
PubTator score by year
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Related Publications
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PMID
Year
Title