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Tbio
NUDT18
8-oxo-dGDP phosphatase NUDT18

Protein Summary
Description
Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611621
  • ENSP00000480722
  • ENSG00000275074

Symbol
  • MTH3
  • MTH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
small molecule perturbation
0.71
biological process
0.64
transcription factor binding site profile
0.63
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.17   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
NUDT5
Tbio
Family:  Enzyme
Novelty:  0.02550535
Score:  0.838
Data Source:  STRINGDB
NUDT15
Tbio
Family:  Enzyme
Novelty:  0.008497
Score:  0.826
Data Source:  STRINGDB
NUDT17
Tdark
Novelty:  0.87396148
Score:  0.744
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.714
Data Source:  STRINGDB
NUDT1
Tchem
Family:  Enzyme
Novelty:  0.00383386
Score:  0.697
Data Source:  STRINGDB
NUDT14
Tbio
Family:  Enzyme
Novelty:  0.11929401
Score:  0.634
Data Source:  STRINGDB
NUDT22
Tbio
Novelty:  0.44528464
Score:  0.615
Data Source:  STRINGDB
NUDT8
Tdark
Novelty:  0.76306116
Score:  0.596
Data Source:  STRINGDB
NUDT2
Tbio
Family:  Enzyme
Novelty:  0.0201004
Score:  0.58
Data Source:  STRINGDB
NUDT9
Tbio
Family:  Enzyme
Novelty:  0.0482661
Score:  0.546
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NUDT proteins
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NUDT proteins
Purine catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
94.5
serum alanine aminotransferase measurement
2
2
1
7
75
low density lipoprotein cholesterol measurement
4
4
4
74
apolipoprotein B measurement
2
2
2
72.8
3
2
3
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
94.5
serum alanine aminotransferase measurement
1
7
75
low density lipoprotein cholesterol measurement
4
74
apolipoprotein B measurement
2
72.8
3
63
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nudix hydrolase 18
707061
Mouse
MGI:2385853
213484
Rat
RGD:1311802
361068
Dog
nudix hydrolase 18
VGNC:44031
609139
Horse
nudix hydrolase 18
VGNC:50735
100056631
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nudix hydrolase 18
Mouse
Rat
Dog
nudix hydrolase 18
Horse
nudix hydrolase 18
Publication Statistics
PubMed Score 4.17
PubMed score by year
PubTator Score 1.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title