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Tdark
ESPNL
Espin-like protein

Protein Summary
Description
Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343063
  • ENSP00000339115
  • ENSG00000144488
  • ENST00000409169
  • ENSP00000386577
  • ENST00000409506
  • ENSP00000386579
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
virus perturbation
0.68
cell line
0.55
tissue sample
0.54
tissue
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.2   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
espin like
695742
Mouse
MGI:2685402
227357
Rat
RGD:1562432
301606
Horse
espin like [Source:HGNC Symbol;Acc:HGNC:27937]
Cow
espin like
VGNC:28604
524380
Species
Name
OMA
EggNOG
Inparanoid
Macaque
espin like
Mouse
Rat
Horse
espin like [Source:HGNC Symbol;Acc:HGNC:27937]
Cow
espin like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZVH7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (67)
1 – 10 of 67
DUSP27
Tdark
Family: Enzyme
Novelty: 0.38303187
Score: 0.736
Data Source: STRINGDB
DUPD1
Tbio
Family: Enzyme
Novelty: 0.2115789
Score: 0.702
Data Source: STRINGDB
ZBTB7C
Tbio
Family: TF
Novelty: 0.1675746
Score: 0.675
Data Source: STRINGDB
GLRB
Tclin
Family: IC
Novelty: 0.01721113
Score: 0.668
Data Source: STRINGDB
MRVI1
Tbio
Novelty: 0.02987514
Score: 0.651
Data Source: STRINGDB
MYO3A
Tbio
Family: Kinase
Novelty: 0.0364819
Score: 0.641
Data Source: STRINGDB
MYO3B
Tbio
Family: Kinase
Novelty: 0.1365033
Score: 0.639
Data Source: STRINGDB
ARL16
Tdark
Family: Enzyme
Novelty: 0.37393252
Score: 0.63
Data Source: STRINGDB
TRIOBP
Tbio
Novelty: 0.04145641
Score: 0.616
Data Source: STRINGDB
FSCN2
Tbio
Novelty: 0.04059985
Score: 0.612
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.20

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer