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Tbio
PHLPP2
PH domain leucine-rich repeat-containing protein phosphatase 2

Protein Summary
Description
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its k ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393524
  • ENSP00000377159
  • ENSG00000040199
  • ENST00000568954
  • ENSP00000457991

Symbol
  • KIAA0931
  • PHLPPL
  • PPM3B
  • PHLPPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
virus perturbation
0.79
microRNA
0.71
tissue sample
0.67
tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.02   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (83)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Negative regulation of the PI3K/AKT network
Reactome
PIP3 activates AKT signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Negative regulation of the PI3K/AKT network
PIP3 activates AKT signaling
Signal Transduction
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (133)
1 – 10 of 133
USP46
Tbio
Family: Enzyme
Novelty: 0.05497502
p_int: 0.999999987
p_ni: 6e-9
p_wrong: 7e-9
Score: 0.757
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01296563
p_int: 0.999999978
p_ni: 2.2e-8
Score: 0.581
Data Source: BioPlex,STRINGDB
LRRC6
Tbio
Novelty: 0.04811765
p_int: 0.998130496
p_ni: 5.99e-7
p_wrong: 0.001868905
Score: 0.562
Data Source: BioPlex,STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.0000383
Score: 0.994
Data Source: Reactome,STRINGDB
AKT3
Tchem
Family: Kinase
Novelty: 0.00482543
Score: 0.986
Data Source: STRINGDB
AKT2
Tchem
Family: Kinase
Novelty: 0.00224767
Score: 0.962
Data Source: STRINGDB
PHLPP1
Tchem
Family: Enzyme
Novelty: 0.00440071
Score: 0.913
Data Source: STRINGDB
CAP1
Tbio
Family: Enzyme
Novelty: 0.03666609
Score: 0.833
Data Source: STRINGDB
CAP2
Tbio
Family: Enzyme
Novelty: 0.21052632
Score: 0.833
Data Source: STRINGDB
WDR20
Tbio
Novelty: 0.00178364
Score: 0.758
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.02

PubMed score by year
PubTator Score  25.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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