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Tbio
PHLPP2
PH domain leucine-rich repeat-containing protein phosphatase 2

Protein Summary
Description
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427). Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499). Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its k ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393524
  • ENSP00000377159
  • ENSG00000040199
  • ENST00000568954
  • ENSP00000457991

Symbol
  • KIAA0931
  • PHLPPL
  • PPM3B
  • PHLPPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
virus perturbation
0.79
microRNA
0.71
tissue sample
0.67
tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.61   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.61   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.999999987
p_ni:  6e-9
p_wrong:  7e-9
Score:  0.757
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999999978
p_ni:  2.2e-8
Score:  0.581
Data Source:  BioPlex,STRINGDB
LRRC6
Tbio
Novelty:  0.10994386
p_int:  0.998130496
p_ni:  5.99e-7
p_wrong:  0.001868905
Score:  0.562
Data Source:  BioPlex,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.994
Data Source:  Reactome,STRINGDB
AKT3
Tchem
Family:  Kinase
Novelty:  0.00308931
Score:  0.986
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.962
Data Source:  STRINGDB
PHLPP1
Tchem
Family:  Enzyme
Novelty:  0.00747239
Score:  0.913
Data Source:  STRINGDB
CAP1
Tbio
Family:  Enzyme
Novelty:  0.0333464
Score:  0.833
Data Source:  STRINGDB
CAP2
Tbio
Family:  Enzyme
Novelty:  0.1142507
Score:  0.833
Data Source:  STRINGDB
WDR20
Tbio
Novelty:  0.03031804
Score:  0.758
Data Source:  STRINGDB
Pathways (83)
Intracellular signaling by second messengers (R-HSA-9006925)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
Negative regulation of the PI3K/AKT network
Reactome
PIP3 activates AKT signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
Negative regulation of the PI3K/AKT network
PIP3 activates AKT signaling
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
2
4
5
92.5
low density lipoprotein cholesterol measurement
3
4
5
90.5
serum metabolite measurement
2
1
2
74.8
apolipoprotein B measurement
1
2
2
71.9
alcohol consumption measurement
2
2
2
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
5
92.5
low density lipoprotein cholesterol measurement
5
90.5
serum metabolite measurement
2
74.8
apolipoprotein B measurement
2
71.9
alcohol consumption measurement
2
71.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PH domain and leucine rich repeat protein phosphatase 2
707575
Mouse
MGI:2444928
244650
Rat
RGD:1562857
498949
Dog
PH domain and leucine rich repeat protein phosphatase 2
VGNC:44505
489724
Horse
PH domain and leucine rich repeat protein phosphatase 2
VGNC:21398
100054529
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PH domain and leucine rich repeat protein phosphatase 2
Mouse
Rat
Dog
PH domain and leucine rich repeat protein phosphatase 2
Horse
PH domain and leucine rich repeat protein phosphatase 2
Publication Statistics
PubMed Score 54.61
PubMed score by year
PubTator Score 25.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title