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Tdark
LHFPL2
LHFPL tetraspan subfamily member 2 protein

Protein Summary
Description
Plays a role in female and male fertility. Involved in distal reproductive tract development. This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380345
  • ENSP00000369702
  • ENSG00000145685
  • ENST00000515007
  • ENSP00000425906

Symbol
  • KIAA0206
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.85
kinase perturbation
0.84
transcription factor binding site profile
0.79
microRNA
0.76
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
98.4
1
1
0
3.4
63.3
age at onset
1
1
0
3.4
63.3
platelet crit
2
2
2
62.6
platelet count
1
1
1
38.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
98.4
0
3.4
63.3
age at onset
0
3.4
63.3
platelet crit
2
62.6
platelet count
1
38.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LHFPL tetraspan subfamily member 2
709040
Mouse
MGI:2145236
218454
Rat
RGD:1309869
294643
Dog
LHFPL tetraspan subfamily member 2
VGNC:42658
610427
Horse
LHFPL tetraspan subfamily member 2 [Source:HGNC Symbol;Acc:HGNC:6588]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LHFPL tetraspan subfamily member 2
Mouse
Rat
Dog
LHFPL tetraspan subfamily member 2
Horse
LHFPL tetraspan subfamily member 2 [Source:HGNC Symbol;Acc:HGNC:6588]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZUX7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Protein-Protein Interactions (42)
1 – 10 of 42
RAB43
Tbio
Family: Enzyme
Novelty: 0.07527576
p_int: 0.999995867
p_ni: 0.000004131
p_wrong: 2e-9
Data Source: BioPlex
ATP2B4
Tbio
Family: Transporter
Novelty: 0.00560356
p_int: 0.999961361
p_ni: 0.000038639
Data Source: BioPlex
SKA3
Tbio
Novelty: 0.05435653
p_int: 0.999945049
p_ni: 0.000039074
p_wrong: 0.000015877
Data Source: BioPlex
MAGEF1
Tdark
Novelty: 0.5133514
p_int: 0.999636388
p_ni: 0.000034046
p_wrong: 0.000329567
Data Source: BioPlex
SKA1
Tbio
Novelty: 0.01777146
p_int: 0.999267938
p_ni: 0.000589432
p_wrong: 0.000142631
Data Source: BioPlex
THAP11
Tbio
Family: TF
Novelty: 0.0679686
p_int: 0.997681151
p_ni: 0.002318762
p_wrong: 8.7e-8
Data Source: BioPlex
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
p_int: 0.97751969
p_ni: 0.022479978
p_wrong: 3.31e-7
Data Source: BioPlex
VMA21
Tdark
Family: Enzyme
Novelty: 0.46129032
p_int: 0.959014027
p_ni: 0.026419143
p_wrong: 0.01456683
Data Source: BioPlex
PPP2R5D
Tbio
Family: Enzyme
Novelty: 0.03990599
p_int: 0.901618109
p_ni: 0.098381243
p_wrong: 6.47e-7
Data Source: BioPlex
CD63
Tchem
Novelty: 0.00072515
p_int: 0.872721771
p_ni: 0.127231344
p_wrong: 0.000046884
Data Source: BioPlex
Publication Statistics
PubMed Score  1.51

PubMed score by year
PubTator Score  2.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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