Tdark LHFPL2 LHFPL tetraspan subfamily member 2 protein

Protein Summary

Description

Plays a role in female and male fertility. Involved in distal reproductive tract development. This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6ZUX7
• B2RMQ6
• Q7Z5P0
• Q92605

Gene Name

• LHFPL2

Ensembl ID

• ENST00000380345
• ENSP00000369702
• ENSG00000145685
• ENST00000515007
• ENSP00000425906

Symbol

• KIAA0206

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.85
kinase perturbation	0.84
transcription factor binding site profile	0.79
microRNA	0.76
transcription factor	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.34   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0