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Tbio
DENND5B
DENN domain-containing protein 5B

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354285
  • ENSP00000346238
  • ENSG00000170456
  • ENST00000389082
  • ENSP00000373734
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
microRNA
0.78
molecular function
0.73
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
80.8
1
1
0
1.4
25.9
intelligence
1
1
1
20.2
1
1
1
20.2
self reported educational attainment
1
1
1
20.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
80.8
0
1.4
25.9
intelligence
1
20.2
1
20.2
self reported educational attainment
1
20.2
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (47)
1 – 10 of 47
RAB39B
Tbio
Family: Enzyme
Novelty: 0.02362498
Score: 0.918
Data Source: STRINGDB
RAB39A
Tbio
Family: Enzyme
Novelty: 0.17719547
Score: 0.915
Data Source: Reactome,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.903
Data Source: Reactome,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
Score: 0.903
Data Source: Reactome,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.9
Data Source: Reactome,STRINGDB
GDI1
Tbio
Novelty: 0.01710945
Score: 0.9
Data Source: Reactome,STRINGDB
ZMYM4
Tbio
Novelty: 0.08839944
Score: 0.772
Data Source: STRINGDB
UFSP2
Tbio
Family: Enzyme
Novelty: 0.12630722
Score: 0.768
Data Source: STRINGDB
OTUD3
Tbio
Novelty: 0.11839931
Score: 0.742
Data Source: STRINGDB
NUBPL
Tbio
Novelty: 0.01059986
Score: 0.721
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.19

PubMed score by year
PubTator Score  0.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer