Tbio ARHGAP27 Rho GTPase-activating protein 27

Protein Summary

Description

Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q6ZUM4
• A4FU35
• A8K3N5
• C9JTF3
• Q494U0
• Q6NWZ8
• Q8WY58

Gene Name

• ARHGAP27

Ensembl ID

• ENST00000290470
• ENSP00000290470
• ENSG00000159314
• ENST00000376922
• ENSP00000366121
• ENST00000428638
• ENSP00000403323
• ENST00000528273
• ENSP00000436137
• ENST00000610792
• ENSP00000477741
• ENSG00000276907
• ENST00000611188
• ENSP00000481302
• ENST00000612916
• ENSP00000480582
• ENSG00000276836
• ENST00000616021
• ENSP00000478738
• ENST00000633003
• ENSP00000487991

Symbol

• CAMGAP1
• SH3D20
• PP905
• SH3D20
• SH3P20
• CAMGAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor	0.81
transcription factor binding site profile	0.72
tissue sample	0.66
cell type or tissue	0.62

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 27

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rho Gtpase-activating Protein 27

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.35   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.35   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0