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Tdark
TMEM26
Transmembrane protein 26

Protein Summary
Description
This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399298
  • ENSP00000382237
  • ENSG00000196932
  • ENST00000488505
  • ENSP00000426071
  • ENST00000503886
  • ENSP00000425286
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
microRNA
0.9
gene perturbation
0.68
tissue sample
0.64
histone modification site profile
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
2
2
32.8
age at first sexual intercourse measurement
1
1
1
30.2
body mass index
1
1
1
12.1
heel bone mineral density
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
2
32.8
age at first sexual intercourse measurement
1
30.2
body mass index
1
12.1
heel bone mineral density
1
4.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 26
VGNC:5822
450483
Macaque
transmembrane protein 26
699011
Mouse
MGI:2143537
327766
Rat
RGD:1309273
309724
Dog
transmembrane protein 26
VGNC:47562
489000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 26
Macaque
transmembrane protein 26
Mouse
Rat
Dog
transmembrane protein 26
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZUK4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (35)
1 – 10 of 35
TNFRSF9
Tbio
Novelty:  0.00162382
Score:  0.823
Data Source:  STRINGDB
CIDEA
Tbio
Novelty:  0.00901749
Score:  0.776
Data Source:  STRINGDB
UCP1
Tbio
Novelty:  0.00055954
Score:  0.773
Data Source:  STRINGDB
PRDM16
Tbio
Family:  TF; Epigenetic
Novelty:  0.00261891
Score:  0.772
Data Source:  STRINGDB
TBX1
Tbio
Family:  TF
Novelty:  0.00154882
Score:  0.75
Data Source:  STRINGDB
MPZL2
Tbio
Novelty:  0.04279356
Score:  0.691
Data Source:  STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
Score:  0.673
Data Source:  STRINGDB
HOXC9
Tbio
Family:  TF
Novelty:  0.02524418
Score:  0.666
Data Source:  STRINGDB
LHX8
Tbio
Family:  TF
Novelty:  0.01815234
Score:  0.662
Data Source:  STRINGDB
FNDC5
Tbio
Novelty:  0.0015827
Score:  0.621
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.53

PubMed score by year
PubTator Score  4.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer