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Tbio
PIK3AP1
Phosphoinositide 3-kinase adapter protein 1

Protein Summary
Description
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339364
  • ENSP00000339826
  • ENSG00000155629
  • ENST00000371109
  • ENSP00000360150
  • ENST00000371110
  • ENSP00000360151

Symbol
  • BCAP
  • BCAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
transcription factor binding site profile
0.74
tissue sample
0.72
transcription factor perturbation
0.68
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.14   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.14   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999999999
p_ni:  1e-9
Score:  0.92
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999984
p_ni:  3e-9
p_wrong:  1.3e-8
Score:  0.724
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999968
p_ni:  5e-9
p_wrong:  2.7e-8
Score:  0.393
Data Source:  BioPlex,STRINGDB
WNT7A
Tbio
Novelty:  0.00421662
p_int:  0.968676396
p_ni:  0.000004818
p_wrong:  0.031318786
Score:  0.195
Data Source:  BioPlex,STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
Score:  0.98
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.971
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.962
Data Source:  Reactome,STRINGDB
BLNK
Tbio
Novelty:  0.00351169
Score:  0.945
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.931
Data Source:  STRINGDB
CD19
Tclin
Novelty:  0.0001816
Score:  0.927
Data Source:  STRINGDB
Pathways (19)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Constitutive Signaling by Aberrant PI3K in Cancer
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
3
3
79.4
serum alanine aminotransferase measurement
3
2
2
7.7
74
lymphocyte count
2
1
2
59
lymphocyte percentage of leukocytes
1
1
1
48.5
aspartate aminotransferase measurement
1
1
0
6.2
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
3
79.4
serum alanine aminotransferase measurement
2
7.7
74
lymphocyte count
2
59
lymphocyte percentage of leukocytes
1
48.5
aspartate aminotransferase measurement
0
6.2
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide-3-kinase adaptor protein 1
VGNC:5630
450646
Macaque
phosphoinositide-3-kinase adaptor protein 1
705017
Mouse
MGI:1933177
83490
Rat
RGD:1307744
294048
Dog
phosphoinositide-3-kinase adaptor protein 1
VGNC:44550
608653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoinositide-3-kinase adaptor protein 1
Macaque
phosphoinositide-3-kinase adaptor protein 1
Mouse
Rat
Dog
phosphoinositide-3-kinase adaptor protein 1
Publication Statistics
PubMed Score 8.14
PubMed score by year
PubTator Score 16.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title