You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TPGS1
Tubulin polyglutamylase complex subunit 1

Protein Summary
Description
May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359315
  • ENSP00000352265
  • ENSG00000141933

Symbol
  • C19orf20
  • PGs1
  • C19orf20
  • GTRGEO22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.84
histone modification site profile
0.82
cell line
0.65
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (28)
1 – 10 of 28
NICN1
Tdark
Novelty: 0.60606061
p_int: 0.999999922
p_ni: 7.8e-8
Score: 0.982
Data Source: BioPlex,STRINGDB
LRRC49
Tdark
Novelty: 0.23026316
p_int: 0.999999865
p_ni: 1.17e-7
p_wrong: 1.7e-8
Score: 0.991
Data Source: BioPlex,STRINGDB
TTLL1
Tdark
Family: Enzyme
Novelty: 0.14944557
p_int: 0.99999705
p_ni: 0.000002949
Score: 0.979
Data Source: BioPlex,STRINGDB
EIF3F
Tbio
Novelty: 0.03659119
p_int: 0.999596446
p_ni: 0.000403535
p_wrong: 2e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
SMG8
Tdark
Novelty: 0.3
p_int: 0.798718778
p_ni: 0.00016955
p_wrong: 0.201111671
Score: 0.815
Data Source: BioPlex,STRINGDB
TPGS2
Tdark
Family: Enzyme
Novelty: 1
Score: 0.9
Data Source: STRINGDB
TTC13
Tdark
Score: 0.775
Data Source: STRINGDB
OR4K15
Tdark
Family: oGPCR
Novelty: 4
Score: 0.757
Data Source: STRINGDB
COX14
Tbio
Family: Enzyme
Novelty: 0.13817305
Score: 0.726
Data Source: STRINGDB
MP68
Tbio
Novelty: 0.01746725
Score: 0.718
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.67

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer