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Tbio
RASSF6
Ras association domain-containing protein 6

Protein Summary
Description
Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B (By similarity). This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307439
  • ENSP00000303877
  • ENSG00000169435
  • ENST00000335049
  • ENSP00000335582
  • ENST00000342081
  • ENSP00000340578
  • ENST00000395777
  • ENSP00000379123
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
cell type or tissue
0.62
microRNA
0.62
histone modification site profile
0.61
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.97   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.97   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
KDM3A
Tchem
Family:  Epigenetic
Novelty:  0.0101705
p_int:  0.999997134
p_ni:  0.000002741
p_wrong:  1.25e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
p_int:  0.999982432
p_ni:  0.000017568
Score:  0.827
Data Source:  BioPlex,STRINGDB
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
p_int:  0.999954454
p_ni:  0.000045546
Score:  0.963
Data Source:  BioPlex,STRINGDB
RASSF10
Tbio
Novelty:  0.05161283
Score:  0.806
Data Source:  STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
Score:  0.798
Data Source:  STRINGDB
MOAP1
Tbio
Novelty:  0.05070263
Score:  0.743
Data Source:  STRINGDB
SAV1
Tbio
Novelty:  0.00962335
Score:  0.74
Data Source:  STRINGDB
RASSF8
Tbio
Novelty:  0.09245647
Score:  0.714
Data Source:  STRINGDB
ENDOG
Tbio
Family:  Enzyme
Novelty:  0.00404275
Score:  0.71
Data Source:  STRINGDB
ANKRD17
Tbio
Novelty:  0.03177323
Score:  0.683
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
2
8
73.2
total cholesterol measurement
1
2
2
64
2
1
0
1.1
63.4
esterified cholesterol measurement
2
1
2
2.3
free cholesterol measurement
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
73.2
total cholesterol measurement
2
64
0
1.1
63.4
esterified cholesterol measurement
2
2.3
free cholesterol measurement
1
0.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras association domain family member 6
VGNC:12995
471206
Macaque
Ras association domain family member 6
704459
Mouse
MGI:1920496
73246
Rat
RGD:1566082
305251
Dog
Ras association domain family member 6
VGNC:45383
482195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras association domain family member 6
Macaque
Ras association domain family member 6
Mouse
Rat
Dog
Ras association domain family member 6
Publication Statistics
PubMed Score 27.97
PubMed score by year
PubTator Score 19.41
PubTator score by year
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Related Publications
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PMID
Year
Title