ANKRD13D
Ankyrin repeat domain-containing protein 13D
Protein Summary
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. The protein encoded by this gene is a member of the ankyrin repeat domain (ANKRD) 13 family, which currently consists of four proteins containing ubiquitin-interacting motifs. These proteins are integral membrane proteins that bind specifically to Lys-63-linked ubiquitin chains on membrane-bound proteins, targeting those proteins for rapid internalization. [provided by RefSeq, Dec 2016]
- ENST00000308440
- ENSP00000310874
- ENSG00000172932
- ENST00000447274
- ENSP00000402616
- ENST00000511455
- ENSP00000427130
- ENST00000514166
- ENSP00000444404
- ENST00000515828
- ENSP00000443977
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.72 | ||
cell line | 0.69 | ||
transcription factor binding site profile | 0.65 | ||
tissue sample | 0.63 | ||
transcription factor | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.64 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 50 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.64 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 50 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0