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Tdark
TMPPE
Transmembrane protein with metallophosphoesterase domain

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342462
  • ENSP00000343398
  • ENSG00000188167
  • ENST00000416695
  • ENSP00000400715
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
microRNA
0.68
tissue
0.65
tissue sample
0.56
cell line
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
4
5
95.4
eosinophil percentage of leukocytes
2
3
3
90.9
5
3
0
1.1
89.3
1
1
0
1.3
73.3
Eczema
2
2
0
1
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
95.4
eosinophil percentage of leukocytes
3
90.9
0
1.1
89.3
0
1.3
73.3
Eczema
0
1
71.1
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein with metallophosphoesterase domain
705812
Mouse
MGI:5317335
100504715
Platypus
transmembrane protein with metallophosphoesterase domain [Source:HGNC Symbol;Acc:HGNC:33865]
Zebrafish
ZDB-GENE-061013-104
569483
C. elegans
181090
Species
Name
OMA
EggNOG
Inparanoid
Macaque
transmembrane protein with metallophosphoesterase domain
Mouse
Platypus
transmembrane protein with metallophosphoesterase domain [Source:HGNC Symbol;Acc:HGNC:33865]
Zebrafish
C. elegans
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZT21-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (29)
1 – 10 of 29
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.968942652
p_ni:  0.03105691
p_wrong:  4.38e-7
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.940747344
p_ni:  0.059252114
p_wrong:  5.42e-7
Data Source:  BioPlex
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.937405466
p_ni:  0.062593693
p_wrong:  8.41e-7
Data Source:  BioPlex
GRIA3
Tclin
Family:  IC
Novelty:  0.00584546
p_int:  0.930473942
p_ni:  0.069525689
p_wrong:  3.69e-7
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.924009897
p_ni:  0.075989813
p_wrong:  2.9e-7
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.888136288
p_ni:  0.111591743
p_wrong:  0.000271969
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.882448178
p_ni:  0.116697599
p_wrong:  0.000854222
Data Source:  BioPlex
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.870751184
p_ni:  0.128262543
p_wrong:  0.000986273
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.868878292
p_ni:  0.131121502
p_wrong:  2.06e-7
Data Source:  BioPlex
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.856909794
p_ni:  0.142605278
p_wrong:  0.000484928
Data Source:  BioPlex
Publication Statistics
PubMed Score  0.19

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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