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Tbio
PPP1R3F
Protein phosphatase 1 regulatory subunit 3F

Protein Summary
Description
Glycogen-targeting subunit for protein phosphatase 1 (PP1). This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000055335
  • ENSP00000055335
  • ENSG00000049769
  • ENST00000376188
  • ENSP00000365359
  • ENST00000466508
  • ENSP00000420687
  • ENST00000495799
  • ENSP00000417535

Symbol
  • R3F
  • HB2E
  • LL0XNC01-7P3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.73
cell type or tissue
0.61
transcription factor
0.57
tissue sample
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.39   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.39   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999791
p_ni:  2.06e-7
p_wrong:  3e-9
Score:  0.893
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999475
p_ni:  5.03e-7
p_wrong:  2.2e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
PPP1R3E
Tdark
Family:  Enzyme
Novelty:  1.19260521
Score:  0.948
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.855
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.855
Data Source:  STRINGDB
PPP1R3D
Tdark
Family:  Enzyme
Novelty:  0.53609018
Score:  0.85
Data Source:  STRINGDB
PPP1R3A
Tbio
Family:  Enzyme
Novelty:  0.03534333
Score:  0.837
Data Source:  STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.834
Data Source:  STRINGDB
PPP1R3C
Tbio
Family:  Enzyme
Novelty:  0.01784199
Score:  0.831
Data Source:  STRINGDB
GYS2
Tbio
Family:  Enzyme
Novelty:  0.01522741
Score:  0.695
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
46.1
childhood onset asthma
1
1
0
1
38.2
mean platelet volume
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46.1
childhood onset asthma
0
1
38.2
mean platelet volume
1
13.5
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859617
54646
Dog
protein phosphatase 1 regulatory subunit 3F
VGNC:44901
491877
Horse
protein phosphatase 1 regulatory subunit 3F [Source:HGNC Symbol;Acc:HGNC:14944]
Cow
protein phosphatase 1 regulatory subunit 3F
VGNC:33247
513859
Pig
protein phosphatase 1 regulatory subunit 3F
100515116
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
protein phosphatase 1 regulatory subunit 3F
Horse
protein phosphatase 1 regulatory subunit 3F [Source:HGNC Symbol;Acc:HGNC:14944]
Cow
protein phosphatase 1 regulatory subunit 3F
Pig
protein phosphatase 1 regulatory subunit 3F
Publication Statistics
PubMed Score 16.39
PubMed score by year
PubTator Score 1.43
PubTator score by year
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Related Publications
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PMID
Year
Title