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Tdark
ZNF621
Zinc finger protein 621

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310898
  • ENSP00000312144
  • ENSG00000172888
  • ENST00000339296
  • ENSP00000340841
  • ENST00000403205
  • ENSP00000386051
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
tissue sample
0.71
protein domain
0.58
tissue
0.57
virus perturbation
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.51   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.51   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
17.8
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
zinc finger protein 621 [Source:HGNC Symbol;Acc:HGNC:24787]
Horse
zinc finger protein 621
VGNC:25360
106781828
Pig
zinc finger protein 621
100623639
Species
Name
OMA
EggNOG
Inparanoid
Dog
zinc finger protein 621 [Source:HGNC Symbol;Acc:HGNC:24787]
Horse
zinc finger protein 621
Pig
zinc finger protein 621
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZSS3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (18)
1 – 10 of 18
TRIM39
Tbio
Family:  Enzyme
Novelty:  0.0837441
p_int:  0.999990977
p_ni:  0.000009023
Score:  0.251
Data Source:  BioPlex,STRINGDB
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.995555696
p_ni:  7e-9
p_wrong:  0.004444296
Data Source:  BioPlex
LRP4
Tbio
Novelty:  0.01336125
p_int:  0.994998259
p_ni:  0.005001741
Score:  0.295
Data Source:  BioPlex,STRINGDB
TRIM27
Tbio
Novelty:  0.02102013
p_int:  0.983917512
p_ni:  0.016082488
Score:  0.218
Data Source:  BioPlex,STRINGDB
TRIM28
Tbio
Family:  Epigenetic
Novelty:  0.00778381
p_int:  0.97904151
p_ni:  0.02095849
Score:  0.923
Data Source:  BioPlex,STRINGDB
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
p_int:  0.952883893
p_ni:  0.047116106
Score:  0.566
Data Source:  BioPlex,STRINGDB
TRUB1
Tbio
Family:  Enzyme
Novelty:  0.07013834
Score:  0.571
Data Source:  STRINGDB
TARBP1
Tbio
Family:  Enzyme
Novelty:  0.04886897
Score:  0.545
Data Source:  STRINGDB
SRBD1
Tbio
Novelty:  0.18931356
Score:  0.477
Data Source:  STRINGDB
NASP
Tbio
Novelty:  0.00902599
Score:  0.443
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.51

PubMed score by year
PubTator Score  0.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer