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Tdark
RNF165
E3 ubiquitin-protein ligase RNF165

Protein Summary
Description
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269439
  • ENSP00000269439
  • ENSG00000141622
  • ENST00000543885
  • ENSP00000444285

Symbol
  • ARKL2
  • Ark2C
  • RNF111L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
microRNA
0.59
tissue sample
0.59
histone modification site profile
0.54
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (30)
1 – 10 of 30
UBE2D2
Tbio
Novelty: 0.00827182
Score: 0.986
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00161137
Score: 0.969
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.961
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00895161
Score: 0.956
Data Source: STRINGDB
UBE2D3
Tbio
Novelty: 0.03222096
Score: 0.897
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00202514
Score: 0.835
Data Source: STRINGDB
UBE2D4
Tbio
Novelty: 0.73170732
Score: 0.799
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.01148413
Score: 0.735
Data Source: STRINGDB
SLC44A1
Tbio
Family: Transporter
Novelty: 0.02115216
Score: 0.715
Data Source: STRINGDB
C18orf25
Tdark
Novelty: 0.45454545
Score: 0.685
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.39

PubMed score by year
PubTator Score  0.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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