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Tdark
RNF165
E3 ubiquitin-protein ligase RNF165

Protein Summary
Description
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269439
  • ENSP00000269439
  • ENSG00000141622
  • ENST00000543885
  • ENSP00000444285

Symbol
  • ARKL2
  • Ark2C
  • RNF111L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
microRNA
0.59
tissue sample
0.59
histone modification site profile
0.54
cell line
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.71   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.986
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.969
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.961
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.956
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.897
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.835
Data Source:  STRINGDB
UBE2D4
Tbio
Novelty:  0.40836104
Score:  0.799
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.735
Data Source:  STRINGDB
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
Score:  0.715
Data Source:  STRINGDB
C18orf25
Tdark
Novelty:  0.67505268
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
4
6
98.2
mean corpuscular volume
2
3
3
92.9
mean platelet volume
2
2
2
90.9
mean reticulocyte volume
1
2
2
88.8
myeloid white cell count
2
2
2
84
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
98.2
mean corpuscular volume
3
92.9
mean platelet volume
2
90.9
mean reticulocyte volume
2
88.8
myeloid white cell count
2
84
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 165
VGNC:5201
455400
Macaque
ring finger protein 165
702104
Mouse
MGI:2444521
225743
Rat
RGD:1560744
307251
Dog
ring finger protein 165
VGNC:53631
490468
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 165
Macaque
ring finger protein 165
Mouse
Rat
Dog
ring finger protein 165
Publication Statistics
PubMed Score 0.71
PubMed score by year
PubTator Score 0.93
PubTator score by year
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Related Publications
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PMID
Year
Title