Tdark RNF165 E3 ubiquitin-protein ligase RNF165

Protein Summary

Description

E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6ZSG1
• B3KVD1

Gene Name

• RNF165

Ensembl ID

• ENST00000269439
• ENSP00000269439
• ENSG00000141622
• ENST00000543885
• ENSP00000444285

Symbol

• ARKL2
• Ark2C
• RNF111L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
microRNA	0.59
tissue sample	0.59
histone modification site profile	0.54
cell line	0.52

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.39   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (5)

1 – 5 of 5

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (12)

Functions (2)

Components (2)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ubiquitin protein ligase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (30)

Explore Interacting Targets

1 – 10 of 30

• See Interactions on String-DB

UBE2D2

Tbio

Novelty: 0.00827182

Score: 0.986

Data Source: STRINGDB

UBC

Tbio

Novelty: 0.00161137

Score: 0.969

Data Source: STRINGDB

UBA52

Tbio

Novelty: 0.01006012

Score: 0.961

Data Source: STRINGDB

UBB

Tbio

Novelty: 0.00895161

Score: 0.956

Data Source: STRINGDB

UBE2D3

Tbio

Novelty: 0.03222096

Score: 0.897

Data Source: STRINGDB

UBE2D1

Tbio

Novelty: 0.00202514

Score: 0.835

Data Source: STRINGDB

UBE2D4

Tbio

Novelty: 0.73170732

Score: 0.799

Data Source: STRINGDB

RPS27A

Tbio

Novelty: 0.01148413

Score: 0.735

Data Source: STRINGDB

SLC44A1

Tbio

Family: Transporter

Novelty: 0.02115216

Score: 0.715

Data Source: STRINGDB

C18orf25

Tdark

Novelty: 0.45454545

Score: 0.685

Data Source: STRINGDB

Publication Statistics

PubMed Score  0.39

PubMed score by year

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PubTator Score  0.93

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Complete proteome
Metal-binding
Nucleus
Reference proteome
Transferase
Ubl conjugation pathway
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

erythrocyte count
granulocyte count
leukocyte count
mean corpuscular hemoglobin
mean corpuscular volume
mean platelet volume
myeloid white cell count
neutrophil count
red blood cell distribution width
reticulocyte count

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging
muscle phenotype
nervous system phenotype
skeleton phenotype