RNF165
E3 ubiquitin-protein ligase RNF165
Protein Summary
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]
- ENST00000269439
- ENSP00000269439
- ENSG00000141622
- ENST00000543885
- ENSP00000444285
- ARKL2
- Ark2C
- RNF111L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.7 | ||
microRNA | 0.59 | ||
tissue sample | 0.59 | ||
histone modification site profile | 0.54 | ||
cell line | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.71 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 130 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.71 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 130 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (30)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (2)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 5 | 4 | 6 | 98.2 | |||||
mean corpuscular volume | 2 | 3 | 3 | 92.9 | |||||
mean platelet volume | 2 | 2 | 2 | 90.9 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 88.8 | |||||
myeloid white cell count | 2 | 2 | 2 | 84 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 98.2 | |||||
mean corpuscular volume | 3 | 92.9 | |||||
mean platelet volume | 2 | 90.9 | |||||
mean reticulocyte volume | 2 | 88.8 | |||||
myeloid white cell count | 2 | 84 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ring finger protein 165 | VGNC:5201 | 455400 | |||||
Macaque | ring finger protein 165 | 702104 | ||||||
Mouse | MGI:2444521 | 225743 | ||||||
Rat | RGD:1560744 | 307251 | ||||||
Dog | ring finger protein 165 | VGNC:53631 | 490468 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ring finger protein 165 | |||||
Macaque | ring finger protein 165 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ring finger protein 165 | |||||
Publication Statistics
PubMed Score 0.71
PubMed score by year
PubTator Score 0.93
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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