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Tbio
WDFY4
WD repeat- and FYVE domain-containing protein 4

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Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.59   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.59   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
95.5
platelet crit
2
2
2
92.7
platelet count
2
2
2
91.2
leukocyte count
2
2
2
84.1
myeloid white cell count
1
1
1
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
95.5
platelet crit
2
92.7
platelet count
2
91.2
leukocyte count
2
84.1
myeloid white cell count
1
78.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
WDFY family member 4
719472
Mouse
MGI:3584510
545030
Dog
WDFY family member 4
VGNC:53018
486770
Cow
WDFY family member 4
527790
Species
Name
OMA
EggNOG
Inparanoid
Macaque
WDFY family member 4
Mouse
Dog
WDFY family member 4
Cow
WDFY family member 4
Protein Structure (0 Structures, 10 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (205)
1 – 10 of 205
MAP1LC3A
Tbio
Novelty:  0.00301583
Score:  0.824
Data Source:  STRINGDB
FMN1
Tbio
Novelty:  0.00130542
Score:  0.82
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.818
Data Source:  STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.818
Data Source:  STRINGDB
DCP1B
Tdark
Novelty:  0.36605365
Score:  0.808
Data Source:  STRINGDB
DCP1A
Tbio
Novelty:  0.02038933
Score:  0.808
Data Source:  STRINGDB
MAP1LC3B2
Tdark
Novelty:  0.30477576
Score:  0.804
Data Source:  STRINGDB
MAP1LC3B
Tbio
Novelty:  0.00101276
Score:  0.804
Data Source:  STRINGDB
GABARAPL2
Tbio
Novelty:  0.0022546
Score:  0.804
Data Source:  STRINGDB
MAP1LC3C
Tbio
Novelty:  0.04062334
Score:  0.804
Data Source:  STRINGDB
Publication Statistics
PubMed Score  9.59

PubMed score by year
PubTator Score  4.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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