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Tbio
RINL
Ras and Rab interactor-like protein

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000591812
  • ENSP00000467107
  • ENSG00000187994
  • ENST00000598904
  • ENSP00000469568
  • ENST00000635328
  • ENSP00000488992
  • ENSG00000282895
  • ENST00000635542
  • ENSP00000489071
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.81
cell type or tissue
0.64
microRNA
0.48
tissue
0.47
cell line
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.23   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0