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Tbio
SRCAP
Helicase SRCAP

Protein Summary
Description
Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262518
  • ENSP00000262518
  • ENSG00000080603

Symbol
  • KIAA0309
  • EAF1
  • FLHS
  • SWR1
  • DOMO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.98
hub protein
0.94
protein domain
0.92
histone modification site profile
0.77


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.35   (req: < 5)
View Publications
Gene RIFs: 18   (req: <= 3)
View Gene RIFs
Antibodies: 80   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.35   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Snf2 related CREBBP activator protein
VGNC:14498
454052
Macaque
Snf2 related CREBBP activator protein
712944
Mouse
Snf2-related CREBBP activator protein
MGI:2444036
100043597
Dog
Snf2 related CREBBP activator protein
479773
Cow
Snf2 related CREBBP activator protein
788113
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Snf2 related CREBBP activator protein
Macaque
Snf2 related CREBBP activator protein
Mouse
Snf2-related CREBBP activator protein
Dog
Snf2 related CREBBP activator protein
Cow
Snf2 related CREBBP activator protein
Protein Structure (0 Structures, 11 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
ATPase activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
histone binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
histone acetyltransferase activity
Traceable Author Statement (TAS)
ProtInc
transcription coactivator activity
Traceable Author Statement (TAS)
ProtInc
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
DNA binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
helicase activity
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (143)
1 – 10 of 143
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999998432
p_ni: 0.000001568
Score: 0.975
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999997416
p_ni: 0.000002584
Score: 0.424
Data Source: BioPlex,STRINGDB
ZNHIT1
Tbio
Novelty: 0.00390514
p_int: 0.99999605
p_ni: 0.00000395
Score: 0.954
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999995734
p_ni: 0.000004266
Score: 0.954
Data Source: BioPlex,STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
p_int: 0.999993828
p_ni: 0.000006172
Score: 0.922
Data Source: BioPlex,STRINGDB
DMAP1
Tbio
Family: Enzyme
Novelty: 0.03152166
p_int: 0.999987222
p_ni: 0.000012778
Score: 0.983
Data Source: BioPlex,STRINGDB
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.999984954
p_ni: 0.000015046
Score: 0.968
Data Source: BioPlex,STRINGDB
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999930422
p_ni: 0.000069578
Score: 0.376
Data Source: BioPlex,STRINGDB
ACTR6
Tbio
Novelty: 0.11005766
p_int: 0.997631288
p_ni: 0.002368712
Score: 0.956
Data Source: BioPlex,STRINGDB
NFATC2IP
Tbio
Novelty: 0.02974299
p_int: 0.995296397
p_ni: 0.004703601
p_wrong: 2e-9
Score: 0.793
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.35

PubMed score by year
PubTator Score  48.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer