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Tdark
OTOG
Otogelin

Protein Summary
Description
Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity). The protein encoded by this gene is a component of the acellular membranes of the inner ear. Disruption of the orthologous mouse gene shows that it plays a role in auditory and vestibular functions. It is involved in fibrillar network organization, the anchoring of otoconial membranes and cupulae to the neuroepithelia, and likely in sound stimulation resistance. Mutations in this gene cause autosomal recessive nonsyndromic deafness, type 18B. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399391
  • ENSP00000382323
  • ENSG00000188162

Symbol
  • OTGN
  • OTGN
  • MLEMP
  • DFNB18B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.61
cell line
0.6
cell type or tissue
0.54
cellular component
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
47.7
age at first sexual intercourse measurement
1
1
1
35
1
1
0
1.9
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
47.7
age at first sexual intercourse measurement
1
35
0
1.9
24.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
otogelin
VGNC:1074
466451
Mouse
MGI:1202064
18419
Rat
RGD:1306610
292918
Dog
otogelin
VGNC:44177
485403
Horse
otogelin
VGNC:21081
100071797
Species
Name
OMA
EggNOG
Inparanoid
Chimp
otogelin
Mouse
Rat
Dog
otogelin
Horse
otogelin
Protein Structure (0 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (51)
1 – 10 of 51
OTOA
Tbio
Novelty:  0.04940755
Score:  0.91
Data Source:  STRINGDB
TECTB
Tbio
Novelty:  0.04489491
Score:  0.856
Data Source:  STRINGDB
USH1C
Tbio
Novelty:  0.01066917
Score:  0.739
Data Source:  STRINGDB
MYO6
Tbio
Novelty:  0.01073438
Score:  0.723
Data Source:  STRINGDB
CEACAM16
Tbio
Novelty:  0.11153655
Score:  0.683
Data Source:  STRINGDB
STRC
Tbio
Novelty:  0.01587212
Score:  0.68
Data Source:  STRINGDB
SERGEF
Tdark
Novelty:  0.36520994
Score:  0.678
Data Source:  STRINGDB
OTOP1
Tbio
Novelty:  0.04916753
Score:  0.661
Data Source:  STRINGDB
ABCC8
Tclin
Family:  Transporter
Novelty:  0.00085572
Score:  0.648
Data Source:  STRINGDB
OTOL1
Tbio
Novelty:  0.05900218
Score:  0.639
Data Source:  STRINGDB
Publication Statistics
PubMed Score  25.59

PubMed score by year
PubTator Score  7.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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