Tbio RNF207 RING finger protein 207

Protein Summary

Description

Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.

Uniprot Accession IDs

• Q6ZRF8
• A2VCM8
• B4DFR6
• Q5TGS6
• Q6ZS63
• Q96MP2

Gene Name

• RNF207

Ensembl ID

• ENST00000377939
• ENSP00000367173
• ENSG00000158286

Symbol

• C1orf188
• C1orf188

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
cell type or tissue	0.71
biological process	0.66
histone modification site profile	0.63
transcription factor binding site profile	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0