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Tbio
DNAH12
Dynein heavy chain 12, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311202
  • ENSP00000312554
  • ENSG00000174844
  • ENST00000351747
  • ENSP00000295937

Symbol
  • DHC3
  • DLP12
  • DNAH12L
  • DNAH7L
  • DNAHC3
  • DNHD2
  • HDHC3
  • HL19
  • DHC3
  • DLP3
  • HL19
  • DLP12
  • DNHD2
  • HDHC3
  • HL-19
  • DNAH7L
  • DNAHC3
  • DNAH12L
  • DNAHC12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
protein domain
0.92
virus perturbation
0.79
gene perturbation
0.71
microRNA
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.48   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.48   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
1
0
29.6
27
monocyte percentage of leukocytes
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
0
29.6
27
monocyte percentage of leukocytes
1
21.4
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (63)
1 – 10 of 63
DNAH14
Tdark
Novelty: 0.28289652
Score: 0.954
Data Source: STRINGDB
DNAH6
Tdark
Novelty: 0.18343511
Score: 0.954
Data Source: STRINGDB
DNAH1
Tbio
Novelty: 0.0369386
Score: 0.954
Data Source: STRINGDB
DNAH5
Tbio
Novelty: 0.01579144
Score: 0.884
Data Source: STRINGDB
DNAL4
Tbio
Novelty: 0.15546154
Score: 0.818
Data Source: STRINGDB
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.795
Data Source: STRINGDB
DNAI1
Tbio
Novelty: 0.01021193
Score: 0.791
Data Source: STRINGDB
DYNC2H1
Tbio
Novelty: 0.01306616
Score: 0.788
Data Source: STRINGDB
DNAH9
Tdark
Novelty: 0.04634487
Score: 0.785
Data Source: STRINGDB
DNAH2
Tbio
Novelty: 0.12847351
Score: 0.779
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.48

PubMed score by year
PubTator Score  9.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer