Tbio GADL1 Acidic amino acid decarboxylase GADL1

Protein Summary

Description

May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate.

Uniprot Accession IDs

• Q6ZQY3

Gene Name

• GADL1

Ensembl ID

• ENST00000282538
• ENSP00000282538
• ENSG00000144644
• ENST00000454381
• ENSP00000427059

Symbol

• ADC
• CSADC
• HuADC
• HuCSADC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
histone modification site profile	0.65
cellular component	0.64
trait	0.61
microRNA	0.56

Protein Classes

PANTHER Classes

Protein / Lyase / Decarboxylase / Acidic Amino Acid Decarboxylase Gadl1

DTO Classes

Protein / Enzyme / Lyase / Decarboxylase / Acidic Amino Acid Decarboxylase Gadl1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.46   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.46   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (84)

Explore Interacting Targets

1 – 10 of 84

• See Interactions on String-DB

OR10A4

Tbio

Family:  oGPCR

Novelty:  0.0796753

p_int:  0.999995055

p_ni:  0.000001321

p_wrong:  0.000003625

Data Source:  BioPlex

OR7A5

Tdark

Family:  oGPCR

Novelty:  1.72860482

p_int:  0.999975085

p_ni:  0.000024116

p_wrong:  7.98e-7

Data Source:  BioPlex

ANKMY2

Tdark

Novelty:  0.50777631

p_int:  0.999868711

p_ni:  0.000131289

Data Source:  BioPlex

RBM14

Tbio

Novelty:  0.01286049

p_int:  0.999168731

p_ni:  0.000830176

p_wrong:  0.000001093

Data Source:  BioPlex

PPP5C

Tbio

Family:  Enzyme

Novelty:  0.01990823

p_int:  0.850368967

p_ni:  0.149631033

Data Source:  BioPlex

ABAT

Tclin

Family:  Enzyme

Novelty:  0.0078359

Score:  0.963

Data Source:  STRINGDB

CDO1

Tbio

Family:  Enzyme

Novelty:  0.01682989

Score:  0.956

Data Source:  STRINGDB

ADO

Tbio

Family:  Enzyme

Novelty:  0.04529593

Score:  0.939

Data Source:  STRINGDB

ALDH7A1

Tbio

Family:  Enzyme

Novelty:  0.00069494

Score:  0.919

Data Source:  STRINGDB

CARNS1

Tbio

Family:  Enzyme

Novelty:  0.09322055

Score:  0.912

Data Source:  STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (1)

1 – 1 of 1

ABAT

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: beta-Alanine metabolism

2: Metabolic pathways

Pathways (9)

Reactome (5)

KEGG (4)

Aspartate and asparagine metabolism (R-HSA-8963693)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aspartate and asparagine metabolism	12 targets	R-HSA-8963693
Reactome	Degradation of cysteine and homocysteine	13 targets	R-HSA-1614558
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Reactome	Sulfur amino acid metabolism	27 targets	R-HSA-1614635

Name	Explore in Pharos	Explore in Source
Aspartate and asparagine metabolism	12 targets	R-HSA-8963693
Degradation of cysteine and homocysteine	13 targets	R-HSA-1614558
Metabolism	2112 targets	R-HSA-1430728
Metabolism of amino acids and derivatives	373 targets	R-HSA-71291
Sulfur amino acid metabolism	27 targets	R-HSA-1614635

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (4)

Components (1)

Processes (2)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
carboxy-lyase activity	Traceable Author Statement (TAS)	Reactome
aspartate 1-decarboxylase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
pyridoxal phosphate binding	Inferred from Electronic Annotation (IEA)	InterPro
sulfinoalanine decarboxylase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	2		69.5
glomerular filtration rate	EFO_0005208	2	2	2		45.5
breast carcinoma	EFO_0000305	2	1	0	1.1	24.5
blood metabolite measurement	EFO_0005664	1	1	1		24.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		69.5
glomerular filtration rate	EFO_0005208	2		45.5
breast carcinoma	EFO_0000305	0	1.1	24.5
blood metabolite measurement	EFO_0005664	1		24.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Decarboxylase
Lyase
Pyridoxal phosphate
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
blood metabolite measurement
breast carcinoma
glomerular filtration rate
heel bone mineral density

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	glutamate decarboxylase like 1	VGNC:1823	470777
Macaque	glutamate decarboxylase like 1		706457
Mouse	glutamate decarboxylase-like 1	MGI:1920998	73748
Dog	glutamate decarboxylase like 1	VGNC:41073	485629
Horse	glutamate decarboxylase like 1	VGNC:18210	100057562

Species	Name	OMA	EggNOG	Inparanoid
Chimp	glutamate decarboxylase like 1
Macaque	glutamate decarboxylase like 1
Mouse	glutamate decarboxylase-like 1
Dog	glutamate decarboxylase like 1
Horse	glutamate decarboxylase like 1

Publication Statistics

PubMed Score 54.46

PubMed score by year

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PubTator Score 12.85

PubTator score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (4)

Items per page:

10

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PMID	Year	Title