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Tdark
LRRC74B
Leucine-rich repeat-containing protein 74B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000442047
  • ENSP00000394078
  • ENSG00000187905
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.77
cell line
0.74
cellular component
0.52
gene perturbation
0.13
biological process
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keratoconus
1
1
1
30.2
mean platelet volume
1
1
1
28.1
1
1
0
1.1
21.5
gut microbiome measurement
1
1
2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Keratoconus
1
30.2
mean platelet volume
1
28.1
0
1.1
21.5
gut microbiome measurement
2
15.8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZQY2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
Hippo-Merlin Signaling Dysregulation
WikiPathways
Pathways Regulating Hippo Signaling
Name
Explore in Pharos
Explore in Source
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
Hippo-Merlin Signaling Dysregulation
Pathways Regulating Hippo Signaling
Protein-Protein Interactions (3)
1 – 3 of 3
HNRNPA1L2
Tdark
Novelty:  0.46233313
Score:  0.789
Data Source:  STRINGDB
AUNIP
Tbio
Family:  Enzyme
Novelty:  1.05114439
Score:  0.74
Data Source:  STRINGDB
MYBPC2
Tbio
Novelty:  0.12558067
Score:  0.588
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.21

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer