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Tchem
IDO2
Indoleamine 2,3-dioxygenase 2

Protein Summary
Description
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885). Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000502986
  • ENSP00000443432
  • ENSG00000188676

Symbol
  • INDOL1
  • INDOL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.59
pathway
0.59
cell line
0.57
molecular function
0.56
tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.24   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.24   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (63)
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.999759724
p_ni:  0.000240275
Score:  0.19
Data Source:  BioPlex,STRINGDB
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.995073929
p_ni:  0.004852827
p_wrong:  0.000073244
Data Source:  BioPlex
ATF1
Tchem
Family:  TF
Novelty:  0.01450941
p_int:  0.992090097
p_ni:  0.007908501
p_wrong:  0.000001402
Score:  0.161
Data Source:  BioPlex,STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.941574635
p_ni:  0.048467459
p_wrong:  0.009957906
Score:  0.181
Data Source:  BioPlex,STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
p_int:  0.924360911
p_ni:  0.075639064
p_wrong:  2.5e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
EME1
Tbio
Family:  Enzyme
Novelty:  0.017415
p_int:  0.915293808
p_ni:  0.084581883
p_wrong:  0.000124309
Score:  0.188
Data Source:  BioPlex,STRINGDB
SMARCA1
Tbio
Novelty:  0.00452148
p_int:  0.87495148
p_ni:  0.12504852
Score:  0.187
Data Source:  BioPlex,STRINGDB
KLF12
Tbio
Family:  TF
Novelty:  0.01924483
p_int:  0.793741509
p_ni:  0.00002725
p_wrong:  0.206231241
Score:  0.622
Data Source:  BioPlex,STRINGDB
FAM171A2
Tdark
Novelty:  1.18763693
p_int:  0.756003239
p_ni:  0.241165826
p_wrong:  0.002830935
Score:  0.175
Data Source:  BioPlex,STRINGDB
TDO2
Tchem
Family:  Enzyme
Novelty:  0.00115832
Score:  0.99
Data Source:  STRINGDB
Pathways (7)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Tryptophan catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Tryptophan catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
46.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
indoleamine 2,3-dioxygenase 2
VGNC:3012
472744
Mouse
MGI:2142489
209176
Rat
RGD:1596771
681319
Dog
indoleamine 2,3-dioxygenase 2
VGNC:41866
482846
Horse
indoleamine 2,3-dioxygenase 2
VGNC:18939
100056686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
indoleamine 2,3-dioxygenase 2
Mouse
Rat
Dog
indoleamine 2,3-dioxygenase 2
Horse
indoleamine 2,3-dioxygenase 2
Publication Statistics
PubMed Score 92.24
PubMed score by year
PubTator Score 88.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title