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Tchem
SLCO4C1
Solute carrier organic anion transporter family member 4C1

Protein Summary
Description
Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. SLCO4C1 belongs to the organic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310954
  • ENSP00000309741
  • ENSG00000173930

Symbol
  • OATP4C1
  • OATPX
  • SLC21A20
  • OATPX
  • OATP-H
  • OATP-M1
  • OATP4C1
  • PRO2176
  • SLC21A20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.7
histone modification site profile
0.64
gene perturbation
0.63
microRNA
0.62
cell type or tissue
0.57


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.91   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 62   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.91   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
digitoxin
Rendered image for digitoxin
Active Ligands (1)
1 – 1 of 1
Digoxigenin
Rendered image for Digoxigenin
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
1
1.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 4C1
VGNC:8651
461972
Macaque
solute carrier organic anion transporter family member 4C1
702748
Mouse
MGI:2442784
227394
Rat
RGD:1303048
432363
Dog
solute carrier organic anion transporter family member 4C1
VGNC:46499
100686528
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier organic anion transporter family member 4C1
Macaque
solute carrier organic anion transporter family member 4C1
Mouse
Rat
Dog
solute carrier organic anion transporter family member 4C1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZQN7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of organic anions
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
SLC-mediated transmembrane transport
Transport of organic anions
Protein-Protein Interactions (173)
1 – 10 of 173
SLC44A2
Tbio
Family:  Transporter
Novelty:  0.01550561
Score:  0.909
Data Source:  STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
Score:  0.908
Data Source:  STRINGDB
ABCA13
Tbio
Family:  Transporter
Novelty:  0.03723754
Score:  0.905
Data Source:  STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
Score:  0.904
Data Source:  STRINGDB
ITGAL
Tclin
Novelty:  0.00099016
Score:  0.903
Data Source:  STRINGDB
SLC2A3
Tchem
Family:  Transporter
Novelty:  0.00229395
Score:  0.903
Data Source:  STRINGDB
CLEC12A
Tbio
Novelty:  0.01478908
Score:  0.903
Data Source:  STRINGDB
HMOX2
Tchem
Family:  Enzyme
Novelty:  0.00180703
Score:  0.903
Data Source:  STRINGDB
CLEC4D
Tbio
Novelty:  0.04119682
Score:  0.903
Data Source:  STRINGDB
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27.91

PubMed score by year
PubTator Score  9.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer