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Tbio
SHLD3
Shieldin complex subunit 3

Protein Summary
Description
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000510585
  • ENSP00000424007
  • ENSG00000253251

Symbol
  • FLJ26957
  • RINN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (10)
1 – 10 of 10
SHLD1
Tbio
Novelty: 1.03046307
Score: 0.875
Data Source: STRINGDB
SHLD2
Tbio
Novelty: 0.55336226
Score: 0.873
Data Source: STRINGDB
MAD2L2
Tbio
Novelty: 0.01091072
Score: 0.75
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.653
Data Source: STRINGDB
ELOB
Tbio
Novelty: 0.01315739
Score: 0.547
Data Source: STRINGDB
RPS27L
Tbio
Novelty: 0.17169978
Score: 0.547
Data Source: STRINGDB
HIGD1A
Tbio
Novelty: 0.06248108
Score: 0.547
Data Source: STRINGDB
PSME3
Tbio
Novelty: 0.01051254
Score: 0.547
Data Source: STRINGDB
ATP5MD
Tbio
Novelty: 0.04489062
Score: 0.547
Data Source: STRINGDB
TRAPPC13
Tdark
Novelty: 0.4415
Score: 0.524
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.30

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer