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Tbio
SHLD3
Shieldin complex subunit 3

Protein Summary
Description
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000510585
  • ENSP00000424007
  • ENSG00000253251

Symbol
  • FLJ26957
  • RINN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
1
1
0
8.2
66.8
feeling tense measurement
1
1
0
6
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
0
8.2
66.8
feeling tense measurement
0
6
31.4
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Zebrafish
ZDB-GENE-041010-187
450064
Species
Name
OMA
EggNOG
Inparanoid
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZNX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (10)
1 – 10 of 10
SHLD1
Tbio
Novelty:  1.03046307
Score:  0.875
Data Source:  STRINGDB
SHLD2
Tbio
Novelty:  0.55336226
Score:  0.873
Data Source:  STRINGDB
MAD2L2
Tbio
Novelty:  0.01091072
Score:  0.75
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.653
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.547
Data Source:  STRINGDB
RPS27L
Tbio
Novelty:  0.17169978
Score:  0.547
Data Source:  STRINGDB
HIGD1A
Tbio
Novelty:  0.06248108
Score:  0.547
Data Source:  STRINGDB
PSME3
Tbio
Novelty:  0.01051254
Score:  0.547
Data Source:  STRINGDB
ATP5MD
Tbio
Novelty:  0.04489062
Score:  0.547
Data Source:  STRINGDB
TRAPPC13
Tdark
Novelty:  0.4415
Score:  0.524
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.30

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer