Tbio FGD5 FYVE, RhoGEF and PH domain-containing protein 5

Protein Summary

Description

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

Uniprot Accession IDs

• Q6ZNL6
• B3KVQ3
• Q6MZY1
• Q7Z303
• Q8IYP3
• Q8N861
• Q8N8G4

Gene Name

• FGD5

Ensembl ID

• ENST00000285046
• ENSP00000285046
• ENSG00000154783

Symbol

• ZFYVE23
• ZFYVE23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.89
protein domain	0.85
microRNA	0.69
tissue sample	0.66
cellular component	0.63

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Fyve, Rhogef And Ph Domain-containing Protein 5

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Fyve, Rhogef And Ph Domain-containing Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.62   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.62   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0