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Tbio
FGD5
FYVE, RhoGEF and PH domain-containing protein 5

Protein Summary
Description
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285046
  • ENSP00000285046
  • ENSG00000154783

Symbol
  • ZFYVE23
  • ZFYVE23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.89
protein domain
0.85
microRNA
0.69
tissue sample
0.66
cellular component
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.12   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.12   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
7
5
1.1
88.2
hemoglobin measurement
2
2
2
84.1
hematocrit
2
2
2
80.3
diastolic blood pressure
3
3
4
78.4
2
3
3
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.1
88.2
hemoglobin measurement
2
84.1
hematocrit
2
80.3
diastolic blood pressure
4
78.4
3
73.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FYVE, RhoGEF and PH domain containing 5
VGNC:7061
460198
Macaque
FYVE, RhoGEF and PH domain containing 5
702022
Mouse
MGI:2443369
232237
Rat
RGD:1305589
362402
Dog
FYVE, RhoGEF and PH domain containing 5
VGNC:40837
484640
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FYVE, RhoGEF and PH domain containing 5
Macaque
FYVE, RhoGEF and PH domain containing 5
Mouse
Rat
Dog
FYVE, RhoGEF and PH domain containing 5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6ZNL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (26)
1 – 10 of 26
PRKACB
Tchem
Family:  Kinase
Novelty:  0.01962222
p_int:  0.962704355
p_ni:  0.037295645
Data Source:  BioPlex
AKAP11
Tbio
Family:  Enzyme
Novelty:  0.0685826
p_int:  0.931745537
p_ni:  0.068254463
Data Source:  BioPlex
DCAF5
Tdark
Novelty:  0.39565074
p_int:  0.773736353
p_ni:  0.226263647
Data Source:  BioPlex
ADGRF5
Tbio
Family:  GPCR
Novelty:  0.08145242
Score:  0.622
Data Source:  STRINGDB
LRRC3B
Tbio
Novelty:  0.05929142
Score:  0.568
Data Source:  STRINGDB
TOPAZ1
Tdark
Novelty:  0.42409276
Score:  0.556
Data Source:  STRINGDB
ARHGEF15
Tbio
Novelty:  0.05771301
Score:  0.544
Data Source:  STRINGDB
ARAP3
Tbio
Novelty:  0.05990082
Score:  0.536
Data Source:  STRINGDB
CTDSPL
Tbio
Family:  Enzyme
Novelty:  0.00471423
Score:  0.526
Data Source:  STRINGDB
NKIRAS1
Tbio
Family:  Enzyme
Novelty:  0.11289799
Score:  0.503
Data Source:  STRINGDB
Publication Statistics
PubMed Score  34.12

PubMed score by year
PubTator Score  1.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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