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Tbio
ATG14
Beclin 1-associated autophagy-related key regulator

Protein Summary
Description
Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604). Modulates the hepatic lipid metabolism (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247178
  • ENSP00000247178
  • ENSG00000126775

Symbol
  • ATG14L
  • KIAA0831
  • ATG14L
  • BARKOR
  • KIAA0831
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.82
kinase perturbation
0.81
cellular component
0.7
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.27   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.27   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
84.9
eosinophil count
1
1
1
77.3
galectin-3 measurement
1
1
1
70.2
eosinophil percentage of leukocytes
1
1
1
38.3
1
1
0
1.1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
84.9
eosinophil count
1
77.3
galectin-3 measurement
1
70.2
eosinophil percentage of leukocytes
1
38.3
0
1.1
3.4
Pathways (8)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (124)
1 – 10 of 124
BECN1
Tbio
Novelty: 0.0003792
p_int: 0.99999999
p_ni: 7e-9
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NRBF2
Tbio
Novelty: 0.02432243
p_int: 0.999999969
p_ni: 2.6e-8
p_wrong: 6e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
p_int: 0.99999991
p_ni: 5.5e-8
p_wrong: 3.6e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
MTFR2
Tbio
Novelty: 0.20272025
p_int: 0.999987422
p_ni: 0.000012474
p_wrong: 1.05e-7
Data Source: BioPlex
CCDC136
Tbio
Novelty: 0.09279967
p_int: 0.999149649
p_ni: 0.000844927
p_wrong: 0.000005424
Data Source: BioPlex
PIK3R4
Tbio
Family: Kinase
Novelty: 0.01412698
p_int: 0.998793241
p_ni: 0.001206759
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
LRRC58
Tdark
Novelty: 2.4415805
p_int: 0.99674972
p_ni: 0.000002686
p_wrong: 0.003247595
Score: 0.219
Data Source: BioPlex,STRINGDB
WDFY1
Tbio
Novelty: 0.13382544
p_int: 0.995656775
p_ni: 0.004343162
p_wrong: 6.3e-8
Data Source: BioPlex
MINK1
Tchem
Family: Kinase
Novelty: 0.00505208
p_int: 0.991641756
p_ni: 0.007868286
p_wrong: 0.000489958
Data Source: BioPlex
MCM10
Tbio
Novelty: 0.0136058
p_int: 0.970522812
p_ni: 0.029128255
p_wrong: 0.000348933
Data Source: BioPlex
Publication Statistics
PubMed Score  92.27

PubMed score by year
PubTator Score  37.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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