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Tbio
AGMO
Alkylglycerol monooxygenase

Protein Summary
Description
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes. The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342526
  • ENSP00000341662
  • ENSG00000187546

Symbol
  • TMEM195
  • TMEM195
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
tissue sample
0.64
trait
0.61
cell line
0.53
microRNA
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.79   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.79   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
77.3
vital capacity
2
2
1
17.6
58.2
1
1
0
1.5
33.6
forced expiratory volume
1
1
1
23.9
adolescent idiopathic scoliosis
1
1
0
1.2
1.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
77.3
vital capacity
1
17.6
58.2
0
1.5
33.6
forced expiratory volume
1
23.9
adolescent idiopathic scoliosis
0
1.2
1.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
alkylglycerol monooxygenase
VGNC:4252
463272
Macaque
alkylglycerol monooxygenase
709963
Mouse
MGI:2442495
319660
Rat
RGD:1312038
362732
Dog
alkylglycerol monooxygenase
VGNC:37706
475247
Species
Name
OMA
EggNOG
Inparanoid
Chimp
alkylglycerol monooxygenase
Macaque
alkylglycerol monooxygenase
Mouse
Rat
Dog
alkylglycerol monooxygenase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZNB7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride biosynthesis
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride biosynthesis
Triglyceride metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (95)
1 – 10 of 95
FA2H
Tbio
Family: Enzyme
Novelty: 0.00449208
Score: 0.929
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
Score: 0.912
Data Source: STRINGDB
PAH
Tclin
Family: Enzyme
Novelty: 0.00337068
Score: 0.818
Data Source: STRINGDB
MSMO1
Tbio
Family: Enzyme
Novelty: 0.01263528
Score: 0.816
Data Source: STRINGDB
QDPR
Tchem
Family: Enzyme
Novelty: 0.00836889
Score: 0.793
Data Source: STRINGDB
CH25H
Tbio
Family: Enzyme
Novelty: 0.01620877
Score: 0.789
Data Source: STRINGDB
ZMAT4
Tdark
Novelty: 0.31281969
Score: 0.774
Data Source: STRINGDB
FAXDC2
Tdark
Family: Enzyme
Novelty: 0.40327406
Score: 0.771
Data Source: STRINGDB
LPCAT2
Tbio
Family: Enzyme
Novelty: 0.02794035
Score: 0.755
Data Source: STRINGDB
SPR
Tchem
Family: Enzyme
Novelty: 0.02144934
Score: 0.738
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.79

PubMed score by year
PubTator Score  13.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer