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Tbio
RNF111
E3 ubiquitin-protein ligase Arkadia

Protein Summary
Description
E3 ubiquitin-protein ligase (PubMed:26656854). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP (PubMed:14657019, PubMed:16601693). Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (PubMed:14657019, PubMed:16601693). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degradation, coupling their activation with degradation, thereby ensuring that only effectors 'in use' are degraded (By similarity). Activates SMAD3/SMAD4-dependent transcription by triggering signal-induced degradation of SNON isoform of SKIL (PubMed:17591695). Associates with UBE2D2 as an E2 enzyme (PubMed:22411132). Specifically binds polysu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348370
  • ENSP00000288199
  • ENSG00000157450
  • ENST00000557998
  • ENSP00000452732
  • ENST00000559209
  • ENSP00000453872
  • ENST00000561186
  • ENSP00000453015

Symbol
  • ARK
  • hRNF111
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
biological process
0.83
microRNA
0.81
molecular function
0.67
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.92   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.92   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphatidylethanolamine measurement
1
2
2
52.7
apolipoprotein A 1 measurement
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphatidylethanolamine measurement
2
52.7
apolipoprotein A 1 measurement
1
16
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 111
VGNC:1887
453477
Macaque
ring finger protein 111
701953
Mouse
MGI:1934919
93836
Rat
RGD:1310097
300813
Dog
ring finger protein 111
VGNC:45621
478323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 111
Macaque
ring finger protein 111
Mouse
Rat
Dog
ring finger protein 111
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6ZNA4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
DNA Repair
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
DNA Repair
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (330)
1 – 10 of 330
CSNK2B
Tbio
Family: Kinase
Novelty: 0.00152367
p_int: 0.999998191
p_ni: 0.000001795
p_wrong: 1.4e-8
Data Source: BioPlex
CSNK2A2
Tchem
Family: Kinase
Novelty: 0.00231447
p_int: 0.999994149
p_ni: 0.000005834
p_wrong: 1.7e-8
Score: 0.205
Data Source: BioPlex,STRINGDB
FAM189B
Tbio
Novelty: 0.21064304
p_int: 0.999957805
p_ni: 0.000021491
p_wrong: 0.000020704
Data Source: BioPlex
UBXN7
Tbio
Novelty: 0.07437638
p_int: 0.999946139
p_ni: 0.000053861
Score: 0.882
Data Source: BioPlex,STRINGDB
UBE2W
Tbio
Novelty: 0.07255713
p_int: 0.999830467
p_ni: 1.52e-7
p_wrong: 0.000169381
Score: 0.927
Data Source: BioPlex,STRINGDB
TPX2
Tbio
Novelty: 0.00435921
p_int: 0.999364525
p_ni: 0.000635464
p_wrong: 1.2e-8
Score: 0.27
Data Source: BioPlex,STRINGDB
DCUN1D5
Tdark
Novelty: 0.56719852
p_int: 0.948596494
p_ni: 0.051375499
p_wrong: 0.000028007
Score: 0.191
Data Source: BioPlex,STRINGDB
TTC9C
Tdark
Novelty: 0.85949913
p_int: 0.948407379
p_ni: 0.049733315
p_wrong: 0.001859306
Score: 0.153
Data Source: BioPlex,STRINGDB
SUGP1
Tbio
Novelty: 0.00434166
p_int: 0.933616351
p_ni: 0.009109862
p_wrong: 0.057273787
Score: 0.175
Data Source: BioPlex,STRINGDB
CGGBP1
Tbio
Novelty: 0.10880271
p_int: 0.904999131
p_ni: 0.094994785
p_wrong: 0.000006084
Score: 0.218
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  39.92

PubMed score by year
PubTator Score  33.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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