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Tbio
AEBP2
Zinc finger protein AEBP2

Protein Summary
Description
DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266508
  • ENSP00000266508
  • ENSG00000139154
  • ENST00000360995
  • ENSP00000354267
  • ENST00000398864
  • ENSP00000381840
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.91
molecular function
0.91
transcription factor perturbation
0.88
transcription factor binding site profile
0.85
cell type or tissue
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
54.4
chronic mountain sickness
1
1
0
2.5
29
gut microbiome measurement
1
1
0
5.7
24.5
diastolic blood pressure
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
54.4
chronic mountain sickness
0
2.5
29
gut microbiome measurement
0
5.7
24.5
diastolic blood pressure
1
12.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
AE binding protein 2
VGNC:8315
465327
Macaque
AE binding protein 2
704080
Mouse
MGI:1338038
11569
Dog
AE binding protein 2
VGNC:37682
486656
Horse
AE binding protein 2
VGNC:15140
100067927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
AE binding protein 2
Macaque
AE binding protein 2
Mouse
Dog
AE binding protein 2
Horse
AE binding protein 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q6ZN18-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Epigenetic regulation of gene expression
Gene expression (Transcription)
PKMTs methylate histone lysines
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (85)
1 – 10 of 85
SUZ12
Tbio
Novelty:  0.00402353
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
JARID2
Tbio
Family:  TF; Epigenetic
Novelty:  0.00921097
p_int:  0.999999947
p_ni:  5e-8
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
p_int:  0.999999498
p_ni:  5e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EED
Tchem
Novelty:  0.00615758
p_int:  0.999998836
p_ni:  0.000001164
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999769525
p_ni:  0.000175525
p_wrong:  0.00005495
Score:  0.467
Data Source:  BioPlex,STRINGDB
ATXN3
Tbio
Novelty:  0.00201109
p_int:  0.999131187
p_ni:  0.000045903
p_wrong:  0.00082291
Score:  0.308
Data Source:  BioPlex,STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.999
Data Source:  Reactome,STRINGDB
EZH1
Tchem
Family:  Epigenetic
Novelty:  0.02636757
Score:  0.993
Data Source:  STRINGDB
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
Score:  0.969
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.77

PubMed score by year
PubTator Score  7.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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