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Tbio
LIN28B
Protein lin-28 homolog B

Protein Classes
Protein Summary
Description
Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345080
  • ENSP00000344401
  • ENSG00000187772

Symbol
  • CSDD2
  • CSDD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.9
gene perturbation
0.86
trait
0.75
interacting protein
0.67
biological term
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.05   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.05   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (67)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated targets of C-MYC transcriptional activation
Name
Explore in Pharos
Explore in Source
Validated targets of C-MYC transcriptional activation
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (74)
1 – 10 of 74
ZC3HAV1
Tbio
Novelty: 0.01794897
p_int: 0.804825757
p_ni: 0.195174242
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
SURF2
Tdark
Novelty: 0.15957447
p_int: 0.77557109
p_ni: 0.22442891
Score: 0.204
Data Source: BioPlex,STRINGDB
TUT4
Tbio
Family: Enzyme
Novelty: 0.0498615
Score: 0.905
Data Source: STRINGDB
TRIM71
Tbio
Family: Enzyme
Novelty: 0.01727233
Score: 0.881
Data Source: STRINGDB
DIS3L2
Tbio
Family: Enzyme
Novelty: 0.0352418
Score: 0.861
Data Source: STRINGDB
HMGA2
Tbio
Family: TF
Novelty: 0.00091535
Score: 0.818
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00050367
Score: 0.816
Data Source: STRINGDB
IGF2BP1
Tbio
Novelty: 0.01140984
Score: 0.8
Data Source: STRINGDB
DICER1
Tbio
Family: Enzyme
Novelty: 0.00042715
Score: 0.796
Data Source: STRINGDB
TUT7
Tbio
Family: Enzyme
Novelty: 0.04755525
Score: 0.784
Data Source: STRINGDB
Publication Statistics
PubMed Score  149.05

PubMed score by year
PubTator Score  116.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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