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Tchem
MAP3K15
Mitogen-activated protein kinase kinase kinase 15

Protein Summary
Description
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338883
  • ENSP00000345629
  • ENSG00000180815

Symbol
  • ASK3
  • ASK3
  • bA723P2.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
protein domain
0.92
tissue sample
0.72
cell line
0.61
phenotype
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (46)
1 – 10 of 46
TNFSF13B
Tclin
Novelty: 0.00069885
p_int: 0.999999995
p_ni: 4e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
SYCE3
Tdark
Novelty: 0.22361224
p_int: 0.999999947
p_ni: 5.2e-8
p_wrong: 2e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
TAAR5
Tchem
Family: GPCR
Novelty: 0.05264805
Score: 0.702
Data Source: STRINGDB
CEMIP2
Tbio
Novelty: 0.04698236
Score: 0.692
Data Source: STRINGDB
DAB2IP
Tbio
Novelty: 0.01423445
Score: 0.686
Data Source: STRINGDB
RASAL2
Tbio
Family: Enzyme
Novelty: 0.03671142
Score: 0.686
Data Source: STRINGDB
SLC25A43
Tbio
Family: Transporter
Novelty: 0.21667475
Score: 0.684
Data Source: STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
Score: 0.66
Data Source: STRINGDB
FRMD7
Tbio
Novelty: 0.01561885
Score: 0.624
Data Source: STRINGDB
NYX
Tbio
Novelty: 0.0100148
Score: 0.608
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.62

PubMed score by year
PubTator Score  10.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer