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Tbio
MAMSTR
MEF2-activating motif and SAP domain-containing transcriptional regulator

Protein Summary
Description
Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318083
  • ENSP00000324175
  • ENSG00000176909
  • ENST00000356751
  • ENSP00000349192
  • ENST00000594582
  • ENSP00000471590

Symbol
  • MASTR
  • MASTR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.58
cell line
0.58
tissue sample
0.54
transcription factor
0.54
cell type or tissue
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
galectin-3 measurement
1
1
1
73.9
1
1
0
1.1
73.6
dentures
2
1
2
53.3
dental caries
1
1
1
46.4
blood protein measurement
1
1
1
41.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
galectin-3 measurement
1
73.9
0
1.1
73.6
dentures
2
53.3
dental caries
1
46.4
blood protein measurement
1
41.9
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MEF2 activating motif and SAP domain containing transcriptional regulator
VGNC:2415
468945
Mouse
MGI:1921740
74490
Rat
RGD:1588652
691041
Dog
MEF2 activating motif and SAP domain containing transcriptional regulator
VGNC:42941
612016
Horse
MEF2 activating motif and SAP domain containing transcriptional regulator
VGNC:19906
100054356
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MEF2 activating motif and SAP domain containing transcriptional regulator
Mouse
Rat
Dog
MEF2 activating motif and SAP domain containing transcriptional regulator
Horse
MEF2 activating motif and SAP domain containing transcriptional regulator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZN01-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (9)
1 – 9 of 9
MYF5
Tbio
Family: TF
Novelty: 0.00229001
Score: 0.649
Data Source: STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.621
Data Source: STRINGDB
MRTFB
Tbio
Novelty: 0.02702072
Score: 0.614
Data Source: STRINGDB
MYOCD
Tbio
Novelty: 0.00354211
Score: 0.547
Data Source: STRINGDB
MRTFA
Tbio
Novelty: 0.00270155
Score: 0.511
Data Source: STRINGDB
MYOD1
Tbio
Family: TF
Novelty: 0.00053412
Score: 0.479
Data Source: STRINGDB
SRF
Tbio
Family: TF
Novelty: 0.00088839
Score: 0.448
Data Source: STRINGDB
BRCA2
Tbio
Novelty: 0.0002217
Score: 0.42
Data Source: STRINGDB
ACIN1
Tbio
Novelty: 0.01675479
Score: 0.407
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.21

PubMed score by year
PubTator Score  5.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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