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Tdark
SPOCD1
SPOC domain-containing protein 1

Protein Summary
Description
This gene encodes a protein that belongs to the TFIIS family of transcription factors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257100
  • ENSP00000257100
  • ENSG00000134668
  • ENST00000360482
  • ENSP00000353670
  • ENST00000533231
  • ENSP00000435851

Symbol
  • PPP1R146
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.56
transcription factor
0.56
cell type or tissue
0.55
cellular component
0.52
transcription factor binding site profile
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.45   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.45   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (20)
1 – 10 of 20
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.642
Data Source:  STRINGDB
UBXN7
Tbio
Novelty:  0.07437638
Score:  0.637
Data Source:  STRINGDB
ZKSCAN2
Tdark
Family:  TF
Novelty:  2.19517974
Score:  0.606
Data Source:  STRINGDB
BPTF
Tchem
Family:  Epigenetic
Novelty:  0.00826037
Score:  0.535
Data Source:  STRINGDB
DNAJC9
Tbio
Novelty:  0.25748073
Score:  0.505
Data Source:  STRINGDB
MIIP
Tbio
Novelty:  0.05079179
Score:  0.505
Data Source:  STRINGDB
ZNF644
Tbio
Family:  TF
Novelty:  0.12816167
Score:  0.486
Data Source:  STRINGDB
RBM15
Tbio
Novelty:  0.00948292
Score:  0.484
Data Source:  STRINGDB
PIN1
Tchem
Family:  Enzyme
Novelty:  0.00957198
Score:  0.471
Data Source:  STRINGDB
KRTAP1-5
Tdark
Novelty:  3.28706369
Score:  0.465
Data Source:  STRINGDB
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
66.6
self reported educational attainment
1
1
1
59.5
smoking status measurement
2
1
2
56.4
gait measurement
1
1
1
53.7
visceral adipose tissue measurement
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
66.6
self reported educational attainment
1
59.5
smoking status measurement
2
56.4
gait measurement
1
53.7
visceral adipose tissue measurement
1
46.9
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPOC domain containing 1
VGNC:1565
456704
Macaque
SPOC domain containing 1
706363
Cow
SPOC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26338]
Pig
SPOC domain containing 1
100739275
Platypus
SPOC domain containing 1
100075322
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPOC domain containing 1
Macaque
SPOC domain containing 1
Cow
SPOC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26338]
Pig
SPOC domain containing 1
Platypus
SPOC domain containing 1
Publication Statistics
PubMed Score 4.45
PubMed score by year
PubTator Score 1.70
PubTator score by year