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Tbio
TRIM72
Tripartite motif-containing protein 72

Protein Summary
Description
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322122
  • ENSP00000312675
  • ENSG00000177238
  • ENST00000613872
  • ENSP00000481813

Symbol
  • MG53
  • MG53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell type or tissue
0.77
cellular component
0.51
molecular function
0.49
tissue
0.48


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.08   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.08   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 72
VGNC:9118
467960
Macaque
tripartite motif containing 72
713623
Mouse
MGI:3612190
434246
Rat
RGD:1562778
365377
Dog
tripartite motif containing 72
VGNC:47838
489927
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 72
Macaque
tripartite motif containing 72
Mouse
Rat
Dog
tripartite motif containing 72
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Protein-Protein Interactions (53)
1 – 10 of 53
DYSF
Tbio
Novelty: 0.00248634
Score: 0.986
Data Source: Reactome,STRINGDB
CAV3
Tbio
Novelty: 0.00190092
Score: 0.982
Data Source: Reactome,STRINGDB
ANXA6
Tbio
Novelty: 0.00286706
Score: 0.954
Data Source: Reactome,STRINGDB
ANXA1
Tbio
Novelty: 0.00103537
Score: 0.953
Data Source: Reactome,STRINGDB
ANXA2
Tbio
Novelty: 0.00103362
Score: 0.949
Data Source: Reactome,STRINGDB
UBE2H
Tbio
Novelty: 0.03259425
Score: 0.753
Data Source: STRINGDB
IRS1
Tbio
Novelty: 0.00048281
Score: 0.744
Data Source: STRINGDB
CAVIN1
Tbio
Family: Enzyme
Novelty: 0.00780634
Score: 0.711
Data Source: STRINGDB
TRAT1
Tbio
Novelty: 0.0015709
Score: 0.687
Data Source: STRINGDB
SLC25A37
Tbio
Family: Transporter
Novelty: 0.01327453
Score: 0.651
Data Source: STRINGDB
Publication Statistics
PubMed Score  101.08

PubMed score by year
PubTator Score  40.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer