Tdark DTHD1 Death domain-containing protein 1

Protein Summary

Description

This gene encodes a protein which contains a death domain. Death domain-containing proteins function in signaling pathways and formation of signaling complexes, as well as the apoptosis pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q6ZMT9
• B2RXK4
• B4E2N7

Gene Name

• DTHD1

Ensembl ID

• ENST00000357504
• ENSP00000350103
• ENSG00000197057
• ENST00000456874
• ENSP00000401597

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.63
trait	0.61
cell line	0.6
tissue sample	0.59
transcription factor	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.71   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 7   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.71   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0