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Tdark
DTHD1
Death domain-containing protein 1

Protein Summary
Description
This gene encodes a protein which contains a death domain. Death domain-containing proteins function in signaling pathways and formation of signaling complexes, as well as the apoptosis pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357504
  • ENSP00000350103
  • ENSG00000197057
  • ENST00000456874
  • ENSP00000401597
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.63
trait
0.61
cell line
0.6
tissue sample
0.59
transcription factor
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
80.3
neutrophil count
2
1
2
79.7
monocyte count
1
1
1
75
leukocyte count
1
1
1
47.9
neutrophil percentage of leukocytes
1
1
1
22.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
80.3
neutrophil count
2
79.7
monocyte count
1
75
leukocyte count
1
47.9
neutrophil percentage of leukocytes
1
22.3
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (19)
1 – 10 of 19
MACC1
Tbio
Novelty: 0.00737376
Score: 0.681
Data Source: STRINGDB
AIPL1
Tbio
Novelty: 0.01436649
Score: 0.569
Data Source: STRINGDB
CNGB1
Tbio
Family: IC
Novelty: 0.01034916
Score: 0.563
Data Source: STRINGDB
SH3BP4
Tbio
Novelty: 0.13130398
Score: 0.552
Data Source: STRINGDB
CHD3
Tbio
Family: Epigenetic
Novelty: 0.00657278
Score: 0.503
Data Source: STRINGDB
UNC5C
Tbio
Novelty: 0.02045906
Score: 0.502
Data Source: STRINGDB
UNC5A
Tbio
Novelty: 0.03749855
Score: 0.496
Data Source: STRINGDB
IFI27
Tbio
Novelty: 0.01718643
Score: 0.478
Data Source: STRINGDB
UNC5CL
Tbio
Novelty: 0.11511991
Score: 0.455
Data Source: STRINGDB
PID1
Tbio
Novelty: 0.01949514
Score: 0.446
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.30

PubMed score by year
PubTator Score  1.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer