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Tchem
KDM7A
Lysine-specific demethylase 7A

Protein Summary
Description
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397560
  • ENSP00000380692
  • ENSG00000006459

Symbol
  • JHDM1D
  • KDM7
  • KIAA1718
  • JHDM1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
transcription factor binding site profile
0.78
histone modification site profile
0.77
molecular function
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.36   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.36   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (168)
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
Score:  0.93
Data Source:  STRINGDB
TRIM24
Tchem
Family:  Epigenetic
Novelty:  0.00532747
Score:  0.918
Data Source:  STRINGDB
KSR1
Tbio
Family:  Kinase
Novelty:  0.00691155
Score:  0.913
Data Source:  STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.913
Data Source:  STRINGDB
ARAF
Tchem
Family:  Kinase
Novelty:  0.00432488
Score:  0.913
Data Source:  STRINGDB
KSR2
Tbio
Family:  Kinase
Novelty:  0.0473668
Score:  0.913
Data Source:  STRINGDB
ATG7
Tchem
Novelty:  0.00120728
Score:  0.909
Data Source:  STRINGDB
TENT4A
Tbio
Family:  Enzyme
Novelty:  0.00526327
Score:  0.909
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.907
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Disease
Diseases of signal transduction
HDMs demethylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
2
2
86.1
platelet count
1
2
2
71.3
4
3
3
1.1
59.7
myeloid white cell count
1
1
1
54.4
monocyte count
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
86.1
platelet count
2
71.3
3
1.1
59.7
myeloid white cell count
1
54.4
monocyte count
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 7A
VGNC:8695
472532
Macaque
lysine demethylase 7A
711830
Mouse
MGI:2443388
338523
Dog
lysine demethylase 7A
VGNC:51806
482769
Horse
lysine demethylase 7A
VGNC:19342
100066113
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 7A
Macaque
lysine demethylase 7A
Mouse
Dog
lysine demethylase 7A
Horse
lysine demethylase 7A
Publication Statistics
PubMed Score 27.36
PubMed score by year
PubTator Score 6.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title