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Tchem
KDM7A
Lysine-specific demethylase 7A

Protein Summary
Description
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397560
  • ENSP00000380692
  • ENSG00000006459

Symbol
  • JHDM1D
  • KDM7
  • KIAA1718
  • JHDM1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
transcription factor binding site profile
0.78
histone modification site profile
0.77
molecular function
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.8   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.8   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Disease
Diseases of signal transduction
HDMs demethylate histones
Gene Ontology Terms (18)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (168)
1 – 10 of 168
BRAF
Tclin
Family: Kinase
Novelty: 0.00382184
Score: 0.93
Data Source: STRINGDB
TRIM24
Tchem
Family: Epigenetic
Novelty: 0.0069628
Score: 0.918
Data Source: STRINGDB
KSR1
Tbio
Family: Kinase
Novelty: 0.0074785
Score: 0.913
Data Source: STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00165174
Score: 0.913
Data Source: STRINGDB
ARAF
Tchem
Family: Kinase
Novelty: 0.00316774
Score: 0.913
Data Source: STRINGDB
KSR2
Tbio
Family: Kinase
Novelty: 0.0686184
Score: 0.913
Data Source: STRINGDB
ATG7
Tbio
Novelty: 0.00164436
Score: 0.909
Data Source: STRINGDB
TENT4A
Tbio
Family: Enzyme
Novelty: 0.00455471
Score: 0.909
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00009742
Score: 0.907
Data Source: STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00028252
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.80

PubMed score by year
PubTator Score  6.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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