Tbio STAC2 SH3 and cysteine-rich domain-containing protein 2

Protein Summary

Description

Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q6ZMT1
• Q32MA3

Gene Name

• STAC2

Ensembl ID

• ENST00000333461
• ENSP00000327509
• ENSG00000141750

Symbol

• 24b2
• 24b2/STAC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	0.71
transcription factor	0.64
PubMedID	0.58
microRNA	0.57
gene perturbation	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.49   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 135   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.49   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0