STAC2
SH3 and cysteine-rich domain-containing protein 2
Protein Summary
Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]
- ENST00000333461
- ENSP00000327509
- ENSG00000141750
- 24b2
- 24b2/STAC2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 0.71 | ||
transcription factor | 0.64 | ||
PubMedID | 0.58 | ||
microRNA | 0.57 | ||
gene perturbation | 0.5 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.48 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.48 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (15)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 3 | 2 | 13 | 92.1 | ||||
creatinine measurement | 2 | 3 | 3 | 85 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 85 | |||||
mean corpuscular volume | 1 | 1 | 1 | 81.2 | |||||
reticulocyte measurement | 2 | 1 | 2 | 68.6 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glomerular filtration rate | 2 | 13 | 92.1 | ||||
creatinine measurement | 3 | 85 | |||||
mean reticulocyte volume | 1 | 85 | |||||
mean corpuscular volume | 1 | 81.2 | |||||
reticulocyte measurement | 2 | 68.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SH3 and cysteine rich domain 2 | VGNC:12699 | 746582 | |||||
Macaque | SH3 and cysteine rich domain 2 | 697044 | ||||||
Mouse | MGI:2144518 | 217154 | ||||||
Rat | RGD:1305548 | 363674 | ||||||
Dog | SH3 and cysteine rich domain 2 | VGNC:46871 | 491029 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SH3 and cysteine rich domain 2 | |||||
Macaque | SH3 and cysteine rich domain 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SH3 and cysteine rich domain 2 | |||||
Publication Statistics
PubMed Score 5.48
PubMed score by year
PubTator Score 2.68
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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