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Tbio
STAC2
SH3 and cysteine-rich domain-containing protein 2

Protein Summary
Description
Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate calcium channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333461
  • ENSP00000327509
  • ENSG00000141750

Symbol
  • 24b2
  • 24b2/STAC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.71
transcription factor
0.64
PubMedID
0.58
microRNA
0.57
gene perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.48   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.48   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
RPL26L1
Tdark
Novelty:  0.75408617
Score:  0.649
Data Source:  STRINGDB
TATDN1
Tbio
Family:  Enzyme
Novelty:  0.12964405
Score:  0.535
Data Source:  STRINGDB
BCAS4
Tbio
Novelty:  0.11759439
Score:  0.514
Data Source:  STRINGDB
MYO19
Tbio
Novelty:  0.13070371
Score:  0.497
Data Source:  STRINGDB
SYT10
Tbio
Novelty:  0.03869283
Score:  0.488
Data Source:  STRINGDB
SHISAL1
Tdark
Novelty:  0.66511357
Score:  0.488
Data Source:  STRINGDB
CHODL
Tbio
Novelty:  0.04842295
Score:  0.462
Data Source:  STRINGDB
LCN10
Tdark
Novelty:  1.32107702
Score:  0.44
Data Source:  STRINGDB
CACNA1E
Tchem
Family:  IC
Novelty:  0.00314898
Score:  0.434
Data Source:  STRINGDB
RPRM
Tbio
Novelty:  0.02938708
Score:  0.432
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
3
2
13
92.1
creatinine measurement
2
3
3
85
mean reticulocyte volume
1
1
1
85
mean corpuscular volume
1
1
1
81.2
reticulocyte measurement
2
1
2
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
13
92.1
creatinine measurement
3
85
mean reticulocyte volume
1
85
mean corpuscular volume
1
81.2
reticulocyte measurement
2
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 and cysteine rich domain 2
VGNC:12699
746582
Macaque
SH3 and cysteine rich domain 2
697044
Mouse
MGI:2144518
217154
Rat
RGD:1305548
363674
Dog
SH3 and cysteine rich domain 2
VGNC:46871
491029
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 and cysteine rich domain 2
Macaque
SH3 and cysteine rich domain 2
Mouse
Rat
Dog
SH3 and cysteine rich domain 2
Publication Statistics
PubMed Score 5.48
PubMed score by year
PubTator Score 2.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title