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Tbio
TMPRSS11A
Transmembrane protease serine 11A

Protein Summary
Description
Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000508048
  • ENSP00000426911
  • ENSG00000187054

Symbol
  • ECRG1
  • HATL1
  • HESP
  • ECRG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.65
interacting protein
0.57
cell type or tissue
0.51
microRNA
0.46


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.2   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.2   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 11A
VGNC:2057
471224
Macaque
transmembrane protease, serine 11A
711430
Mouse
MGI:2684853
194597
Rat
RGD:1596322
686581
Dog
transmembrane serine protease 11A
VGNC:47628
482173
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 11A
Macaque
transmembrane protease, serine 11A
Mouse
Rat
Dog
transmembrane serine protease 11A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6ZMR5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (15)
1 – 10 of 15
ACADL
Tbio
Family: Enzyme
Novelty: 0.0298212
p_int: 0.999955418
p_ni: 0.000044582
Score: 0.534
Data Source: BioPlex,STRINGDB
PSG3
Tbio
Novelty: 0.05846466
p_int: 0.999551875
p_ni: 0.000150215
p_wrong: 0.00029791
Score: 0.299
Data Source: BioPlex,STRINGDB
RSPRY1
Tdark
Novelty: 0.26883105
p_int: 0.991208397
p_ni: 0.008791603
Score: 0.198
Data Source: BioPlex,STRINGDB
TMEM11
Tbio
Novelty: 0.00067837
p_int: 0.955443258
p_ni: 0.01645021
p_wrong: 0.028106532
Score: 0.219
Data Source: BioPlex,STRINGDB
PAK4
Tchem
Family: Kinase
Novelty: 0.0068821
p_int: 0.916365192
p_ni: 0.083634808
Score: 0.221
Data Source: BioPlex,STRINGDB
C2orf40
Tbio
Novelty: 0.02159003
Score: 0.602
Data Source: STRINGDB
ZNF491
Tdark
Family: TF
Novelty: 4.75862069
Score: 0.541
Data Source: STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
Score: 0.527
Data Source: STRINGDB
SPINK7
Tbio
Family: Enzyme
Novelty: 0.02397234
Score: 0.525
Data Source: STRINGDB
RTP1
Tbio
Novelty: 0.0278378
Score: 0.491
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.20

PubMed score by year
PubTator Score  10.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer