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Tbio
AATK
Serine/threonine-protein kinase LMTK1

Protein Summary
Description
May be involved in neuronal differentiation. The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326724
  • ENSP00000324196
  • ENSG00000181409
  • ENST00000374792
  • ENSP00000363924

Symbol
  • AATYK
  • KIAA0641
  • LMR1
  • LMTK1
  • LMR1
  • AATYK
  • LMTK1
  • p35BP
  • AATYK1
  • PPP1R77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.86
disease perturbation
0.83
protein domain
0.73
cell line
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
4
2
6.7
96.9
body mass index
2
2
2
93.4
depressive symptom measurement
1
1
1
82.4
appendicular lean mass
3
1
3
80.9
wellbeing measurement
1
1
1
80.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
6.7
96.9
body mass index
2
93.4
depressive symptom measurement
1
82.4
appendicular lean mass
3
80.9
wellbeing measurement
1
80.8
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (22)
1 – 10 of 22
CDK5
Tchem
Family: Kinase
Novelty: 0.00071394
Score: 0.785
Data Source: STRINGDB
LMF1
Tbio
Family: Enzyme
Novelty: 0.0280811
Score: 0.686
Data Source: STRINGDB
CDK5R1
Tchem
Family: Enzyme
Novelty: 0.01065962
Score: 0.663
Data Source: STRINGDB
CARNS1
Tbio
Family: Enzyme
Novelty: 0.09322055
Score: 0.584
Data Source: STRINGDB
B3GNTL1
Tdark
Family: Enzyme
Novelty: 0.13396783
Score: 0.537
Data Source: STRINGDB
SH3BP5
Tbio
Novelty: 0.00597871
Score: 0.521
Data Source: STRINGDB
AARSD1
Tdark
Novelty: 0.75372406
Score: 0.511
Data Source: STRINGDB
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00153551
Score: 0.506
Data Source: STRINGDB
CSF3
Tbio
Novelty: 0.00011283
Score: 0.505
Data Source: STRINGDB
CARD6
Tbio
Family: Enzyme
Novelty: 0.08868556
Score: 0.485
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.72

PubMed score by year
PubTator Score  10.02

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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