AATK
Serine/threonine-protein kinase LMTK1
Protein Summary
May be involved in neuronal differentiation. The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
- ENST00000326724
- ENSP00000324196
- ENSG00000181409
- ENST00000374792
- ENSP00000363924
- AATYK
- KIAA0641
- LMR1
- LMTK1
- LMR1
- AATYK
- LMTK1
- p35BP
- AATYK1
- PPP1R77
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
gene perturbation | 0.86 | ||
disease perturbation | 0.83 | ||
protein domain | 0.73 | ||
cell line | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 56.4 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 191 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 56.4 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 191 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0