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Tbio
THSD4
Thrombospondin type-1 domain-containing protein 4

Protein Summary
Description
Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261862
  • ENSP00000261862
  • ENSG00000187720
  • ENST00000355327
  • ENSP00000347484
  • ENST00000357769
  • ENSP00000350413

Symbol
  • ADAMTSL6
  • FVSY9334
  • PRO34005
  • ADAMTSL-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
kinase perturbation
0.95
phenotype
0.81
transcription factor perturbation
0.8
disease
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.11   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.11   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
ZNF195
Tdark
Family:  TF
Novelty:  0.23029736
p_int:  0.997219492
p_ni:  0.001704095
p_wrong:  0.001076413
Score:  0.169
Data Source:  BioPlex,STRINGDB
ALMS1
Tbio
Novelty:  0.00694228
p_int:  0.99301258
p_ni:  0.00698742
Data Source:  BioPlex
KRBA1
Tdark
Novelty:  2.59384945
p_int:  0.991440118
p_ni:  0.008540107
p_wrong:  0.000019775
Score:  0.155
Data Source:  BioPlex,STRINGDB
CEP164
Tbio
Novelty:  0.04775724
p_int:  0.983495288
p_ni:  0.016041641
p_wrong:  0.000463071
Data Source:  BioPlex
GLI3
Tbio
Family:  TF
Novelty:  0.00051217
p_int:  0.947541428
p_ni:  0.001430585
p_wrong:  0.051027988
Score:  0.27
Data Source:  BioPlex,STRINGDB
ZNF609
Tdark
Novelty:  0.06635612
p_int:  0.939373255
p_ni:  0.060626436
p_wrong:  3.08e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
FOXG1
Tbio
Family:  TF
Novelty:  0.00154897
p_int:  0.934027111
p_ni:  0.0000929
p_wrong:  0.065879989
Score:  0.204
Data Source:  BioPlex,STRINGDB
APPBP2
Tbio
Novelty:  0.14742368
p_int:  0.917387214
p_ni:  0.082608962
p_wrong:  0.000003824
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.910035982
p_ni:  0.089964018
Data Source:  BioPlex
USP54
Tdark
Family:  Enzyme
Novelty:  0.31344498
p_int:  0.908481073
p_ni:  0.091518927
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
2
2
95.6
2
3
0
1.1
93.2
forced expiratory volume
1
2
2
85.5
peak expiratory flow
1
1
1
84.9
hematocrit
2
1
2
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
95.6
0
1.1
93.2
forced expiratory volume
2
85.5
peak expiratory flow
1
84.9
hematocrit
2
73
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thrombospondin type 1 domain containing 4
VGNC:2461
467719
Mouse
MGI:2672033
207596
Dog
thrombospondin type-1 domain-containing protein 4
487628
Horse
thrombospondin type 1 domain containing 4
VGNC:51434
100063949
Pig
thrombospondin type 1 domain containing 4
100524417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thrombospondin type 1 domain containing 4
Mouse
Dog
thrombospondin type-1 domain-containing protein 4
Horse
thrombospondin type 1 domain containing 4
Pig
thrombospondin type 1 domain containing 4
Publication Statistics
PubMed Score 8.11
PubMed score by year
PubTator Score 3.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title